Drug Information

Drug General Information
Drug ID
D01NUG
Former ID
DNCL002041
Drug Name
GSK870086
Indication Asthma [ICD10:J45] Discontinued in Phase 2 [548295]
Company
GlaxoSmithKline
Target and Pathway
Target(s) Glucocorticoid receptor Target Info Modulator [550860]
KEGG Pathway Neuroactive ligand-receptor interaction
NetPath Pathway IL2 Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class II
FOXA2 and FOXA3 transcription factor networks
Glucocorticoid receptor regulatory network
Regulation of Androgen receptor activity
AP-1 transcription factor network
Reactome BMAL1:CLOCK,NPAS2 activates circadian gene expression
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
SIDS Susceptibility Pathways
Nuclear Receptors Meta-Pathway
Endoderm Differentiation
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Adipogenesis
Circadian Clock
Nuclear Receptors
References
Ref 548295Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024246)
Ref 550860CN patent application no. 102388025, Pyrimidopyridazine derivatives useful as p38 mapk inhibitors.

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