Drug Information

Drug General Information
Drug ID
D01NIR
Former ID
DIB007414
Drug Name
Radotinib
Synonyms
IY-5511; IY-GV50205; Anticancer, Il-yang
Drug Type
Small molecular drug
Indication Leukemia [ICD9: 208.9; ICD10:C90-C95] Phase 3 [523761], [542758]
Company
Il-Yang Pharmaceutical Co
Structure
Download
2D MOL

3D MOL
Formula
C27H21F3N8O
InChI
InChI=1S/C27H21F3N8O/c1-16-3-4-18(9-23(16)37-26-33-6-5-22(36-26)24-13-31-7-8-32-24)25(39)35-20-10-19(27(28,29)30)11-21(12-20)38-14-17(2)34-15-38/h3-15H,1-2H3,(H,35,39)(H,33,36,37)
InChIKey
DUPWHXBITIZIKZ-UHFFFAOYSA-N
CAS Number
CAS 926037-48-1
PubChem Compound ID
16063245
PubChem Substance ID
24704514, 26598690, 29947744, 162108695, 172821461, 198950282, 223366145, 229383674, 243748498, 252451652
Target and Pathway
Target(s) Aurora protein kinase Target Info Modulator
KEGG Pathway Oocyte meiosis
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteins
References
Ref 523761ClinicalTrials.gov (NCT01511289) Radotinib Versus Imatinib in Newly Diagnosed Philadelphia Chromosome and Chronic Myeloid Leukemia Chronic Phase Patients. U.S. National Institutes of Health.
Ref 542758(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7814).

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