| Drug General Information |
| Drug ID |
D01NCC
|
| Former ID |
DIB003463
|
| Drug Name |
Factor-VIIa-XTEN
|
| Synonyms |
FVIIa-XTEN; Factor VIIa modulator (XTEN, hemophilia), Amunix/Biogen
|
| Indication |
Hemophilia [ICD9: 286; ICD10:D66-D68]
|
Investigative |
[1]
|
|---|
| Company |
Amunix Inc
|
| Target and Pathway |
| Target(s) |
Coagulation factor VII |
Target Info |
Modulator |
[1]
|
|---|
|
KEGG Pathway
|
Complement and coagulation cascades
|
|
PANTHER Pathway
|
Angiogenesis
|
|
Blood coagulation
|
|
PathWhiz Pathway
|
Coagulation
|
|
Reactome
|
BMAL1:CLOCK,NPAS2 activates circadian gene expression
|
|
Extrinsic Pathway of Fibrin Clot Formation
|
|
Gamma-carboxylation of protein precursors
|
|
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
|
|
Removal of aminoterminal propeptides from gamma-carboxylated proteins
|
|
WikiPathways
|
Complement and Coagulation Cascades
|
|
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
|
|
Blood Clotting Cascade
|
|
Formation of Fibrin Clot (Clotting Cascade)
|
|
Circadian Clock
|
|
Folate Metabolism
|
|
Vitamin B12 Metabolism
|
|
Selenium Micronutrient Network
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2363). |
|---|
