Drug Information

Drug General Information
Drug ID
D01KZC
Former ID
DIB000318
Drug Name
Minopafant
Synonyms
E-5880
Drug Type
Small molecular drug
Indication Septic shock [ICD9: 785.52; ICD10:A41.9] Discontinued in Phase 2 [545101]
Company
Eisai Co Ltd
Structure
Download
2D MOL

3D MOL
Formula
C46H73ClN4O9
Canonical SMILES
N(C(=O)c1c(OC)cccc1)(C(=O)OC[C@@H](COC(=O)N1CCC(OC(=O)N<br />CCCCCCCCCCCCCCCCCC)CC1)OC)Cc1[n+](CC)cccc1.[Cl-]
CAS Number
CAS 128420-61-1
PubChem Compound ID
130990
Target and Pathway
Target(s) Platelet-activating factor receptor Target Info Antagonist [527485]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
NetPath Pathway IL5 Signaling Pathway
Leptin Signaling Pathway
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
Interferon gamma signaling
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Interferon gamma signaling
GPCR ligand binding
GPCR downstream signaling
References
Ref 545101Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002131)
Ref 527485Formation of spherical micelles composed of the novel platelet activating factor receptor antagonist, E5880. Pharm Dev Technol. 2005;10(1):11-6.

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