Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D01KZC
|
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| Former ID |
DIB000318
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| Drug Name |
Minopafant
|
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| Synonyms |
E-5880
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| Drug Type |
Small molecular drug
|
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| Indication | Septic shock [ICD9: 785.52; ICD10:A41.9] | Discontinued in Phase 2 | [1] | ||
| Company |
Eisai Co Ltd
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C46H73ClN4O9
|
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| Canonical SMILES |
N(C(=O)c1c(OC)cccc1)(C(=O)OC[C@@H](COC(=O)N1CCC(OC(=O)N<br />CCCCCCCCCCCCCCCCCC)CC1)OC)Cc1[n+](CC)cccc1.[Cl-]
|
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| CAS Number |
CAS 128420-61-1
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Platelet-activating factor receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Staphylococcus aureus infection | |||||
| NetPath Pathway | IL5 Signaling Pathway | ||||
| Leptin Signaling Pathway | |||||
| Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
| G alpha (q) signalling events | |||||
| Interferon gamma signaling | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Small Ligand GPCRs | |||||
| Interferon gamma signaling | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002131) | ||||
| REF 2 | Formation of spherical micelles composed of the novel platelet activating factor receptor antagonist, E5880. Pharm Dev Technol. 2005;10(1):11-6. | ||||
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