Drug General Information
Drug ID
D01KQA
Former ID
DAP000380
Drug Name
Nalbuphine
Synonyms
Intapan; Nalbufina; Nalbuphinum; Intapan (TN); Nalbuphine (INN); Nubain (TN); (5alpha,6alpha)-17-(cyclobutylmethyl)-4,5-epoxymorphinan-3,6,14-triol; 17-cyclobutylmethyl-4,5alpha-epoxymorphinan-3,6alpha,14-triol
Drug Type
Small molecular drug
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Approved [538227], [539027]
Therapeutic Class
Analgesics
Company
Endo Pharmaceuticals
Structure
Download
2D MOL

3D MOL

Formula
C21H27NO4
InChI
InChI=1S/C21H27NO4/c23-14-5-4-13-10-16-21(25)7-6-15(24)19-20(21,17(13)18(14)26-19)8-9-22(16)11-12-2-1-3-12/h4-5,12,15-16,19,23-25H,1-3,6-11H2/t15-,16+,19-,20-,21+/m0/s1
InChIKey
NETZHAKZCGBWSS-CEDHKZHLSA-N
CAS Number
CAS 20594-83-6
PubChem Compound ID
PubChem Substance ID
ChEBI ID
ChEBI:7454
SuperDrug ATC ID
N02AF02
SuperDrug CAS ID
cas=020594836
Target and Pathway
Target(s) Kappa-type opioid receptor Target Info Modulator [556264]
KEGG Pathway Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Opioid prodynorphin pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 538227FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 070692.
Ref 539027(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1663).
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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