Drug Information

Drug General Information
Drug ID
D01JUF
Former ID
DAP000299
Drug Name
Phentolamine
Synonyms
Dibasin; Fentolamin; Fentolamina; Phenotolamine; Phentalamine; Phentolaminum; Regitin; Regitine; Regitipe; Regityn; Rogitine; Phentolamine mesylate [USAN]; Phentolamine methanesulfonate; C 7337; C 7337 Ciba; Fentolamina [INN-Spanish]; Phentolamine (INN); Phentolamine [INN:BAN]; Phentolamine, methyl sulfonate; Phentolaminum [INN-Latin]; Vasomax (TN); 2-((N-(m-Hydroxyphenyl)-p-toluidino)methyl)-2-imidazoline; 2-(N'-p-Tolyl-N'-m-hydroxyphenylaminomethyl)-2-imidazoline; 2-(N-(m-Hydroxyphenyl)-p-toluidinomethyl)imidazoline; 2-(m-Hydroxy-N-p-tolylanilinomethyl)-2-imidazoline; 3-[(4,5-dihydro-1H-imidazol-2-ylmethyl)(4-methylphenyl)amino]phenol; 3-[N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-4-methylanilino]phenol
Drug Type
Small molecular drug
Indication Dermal necrosis [ICD10:K05] Approved [468130], [538172]
Therapeutic Class
Antihypertensive Agents
Company
Bedford Laboratories
Structure
Download
2D MOL

3D MOL
Formula
C17H19N3O
InChI
InChI=1S/C17H19N3O/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15/h2-8,11,21H,9-10,12H2,1H3,(H,18,19)
InChIKey
MRBDMNSDAVCSSF-UHFFFAOYSA-N
CAS Number
CAS 50-60-2
PubChem Compound ID
5775
PubChem Substance ID
840956, 860967, 3249474, 5136946, 7980295, 8153547, 11112200, 11335982, 11361221, 11362891, 11365453, 11368015, 11371816, 11374477, 11376177, 11462193, 11466258, 11467378, 11485936, 11490604, 11492714, 11493891, 14848762, 26751465, 26751466, 26751467, 29224810, 46506535, 47424187, 47573329, 47573330, 47720558, 47720559, 47720560, 48018848, 48094496, 48094497, 48169316, 48169317, 48416421, 49698396, 50005392, 50085867, 50100389, 50100390, 50103967, 50103968, 50737406, 53786858, 57322944
SuperDrug ATC ID
C04AB01; V03AB36
SuperDrug CAS ID
cas=000050602
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Antagonist [537387]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 468130(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 502).
Ref 538172FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 040235.
Ref 537387Nesfatin-1 exerts cardiovascular actions in brain: possible interaction with the central melanocortin system. Am J Physiol Regul Integr Comp Physiol. 2009 Aug;297(2):R330-6. Epub 2009 May 27.

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