Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D01JGD
|
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| Former ID |
DIB001844
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| Drug Name |
AD-03
|
||||
| Synonyms |
AFFITOPE AD03; Amyloid beta vaccine (Affitome, Alzheimers disease), AFFiRiS/ GlaxoSmithKline
|
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| Drug Type |
Vaccine
|
||||
| Indication | Alzheimer disease [ICD9: 331; ICD10:G30] | Phase 1 | [1] | ||
| Company |
AFFiRiS AG
|
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| Target and Pathway | |||||
| Target(s) | Amyloid beta A4 protein | Target Info | [2] | ||
| KEGG Pathway | Notch signaling pathway | ||||
| Alzheimer's disease | |||||
| Reactome | Nuclear signaling by ERBB4 | ||||
| Degradation of the extracellular matrix | |||||
| Regulated proteolysis of p75NTR | |||||
| NRIF signals cell death from the nucleus | |||||
| Activated NOTCH1 Transmits Signal to the Nucleus | |||||
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | |||||
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |||||
| EPH-ephrin mediated repulsion of cells | |||||
| WikiPathways | Notch Signaling Pathway | ||||
| Signaling by ERBB4 | |||||
| Signaling by NOTCH3 | |||||
| Signaling by NOTCH4 | |||||
| Signaling by NOTCH1 | |||||
| Signaling by NOTCH2 | |||||
| Notch Signaling Pathway | |||||
| Alzheimers Disease | |||||
| Signalling by NGF | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033932) | ||||
| REF 2 | Disease-modifying drugs in Alzheimer's disease. Drug Des Devel Ther. 2013; 7: 1471-1479. | ||||
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