Drug General Information
Drug ID
D01GZO
Former ID
DNC000077
Drug Name
5-amino orotate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [535811]
Formula
C27H24N4O6
Canonical SMILES
CC1=NC(=O)C2=C(N1)C=CC3=C2C=C(C=C3)CNC4=CC5=C(C=C4)C(=O<br />)N(C5)C(CCC(=O)O)C(=O)O
InChI
1S/C27H24N4O6/c1-14-29-21-7-4-16-3-2-15(10-20(16)24(21)25(34)30-14)12-28-18-5-6-19-17(11-18)13-31(26(19)35)22(27(36)37)8-9-23(32)33/h2-7,10-11,22,28H,8-9,12-13H2,1H3,(H,32,33)(H,36,37)(H,29,30,34)/t22-/m0/s1
InChIKey
BRVFNEZMTRVUGW-QFIPXVFZSA-N
CAS Number
CAS 139987-54-5
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Dihydroorotase Target Info Inhibitor [535811]
References
Ref 535811Antimalarial activity of orotate analogs that inhibit dihydroorotase and dihydroorotate dehydrogenase. Biochem Pharmacol. 1992 Mar 17;43(6):1295-301.
Ref 535811Antimalarial activity of orotate analogs that inhibit dihydroorotase and dihydroorotate dehydrogenase. Biochem Pharmacol. 1992 Mar 17;43(6):1295-301.

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