Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D01GEB
|
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| Former ID |
DNC012867
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| Drug Name |
ROXINDOLE
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| Drug Type |
Small molecular drug
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| Indication | Psychotic disorders [ICD9: 290-299; ICD10:F20-F29] | Phase 2 | [1], [2] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C23H26N2O
|
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| InChI |
InChI=1S/C23H26N2O/c26-21-9-10-23-22(16-21)20(17-24-23)8-4-5-13-25-14-11-19(12-15-25)18-6-2-1-3-7-18/h1-3,6-7,9-11,16-17,24,26H,4-5,8,12-15H2
|
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| InChIKey |
HGEYJZMMUGWEOT-UHFFFAOYSA-N
|
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| CAS Number |
CAS 112192-04-8
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| PubChem Compound ID | |||||
| PubChem Substance ID |
6349747, 9374254, 11114137, 14900636, 30422424, 47583771, 48329099, 49658794, 50916746, 85209757, 103266733, 103847333, 103916479, 113468488, 117617076, 124887037, 127339809, 127339810, 127339811, 128056374, 134222300, 134350072, 135141432, 135650930, 137248627, 142950049, 144204506, 162223603, 170466119, 179149560, 198986031, 223536057, 226433363
|
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| Target and Pathway | |||||
| Target(s) | D(2) dopamine receptor | Target Info | Inhibitor | [3] | |
| KEGG Pathway | Rap1 signaling pathway | ||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Gap junction | |||||
| Dopaminergic synapse | |||||
| Parkinson's disease | |||||
| Cocaine addiction | |||||
| Alcoholism | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Dopamine receptor mediated signaling pathway | |||||
| Nicotine pharmacodynamics pathway | |||||
| Reactome | Dopamine receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | Hypothetical Network for Drug Addiction | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Genes and (Common) Pathways Underlying Drug Addiction | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| Nicotine Activity on Dopaminergic Neurons | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 52). | ||||
| REF 2 | Roxindole: psychopharmacological profile of a dopamine D2 autoreceptor agonist. J Pharmacol Exp Ther. 1996 Jan;276(1):41-8. | ||||
| REF 3 | J Med Chem. 2004 Sep 9;47(19):4677-83.Indolebutylamines as selective 5-HT(1A) agonists. | ||||
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