Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D01DVX
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| Former ID |
DPR000038
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| Drug Name |
DPC-333
|
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| Drug Type |
Small molecular drug
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| Indication | Inflammatory bowel disease; Rheumatoid arthritis [ICD9: 555, 556, 710-719, 714; ICD10:K50, K51, M00-M25, M05-M06] | Terminated | [1], [2] | ||
| Company |
Bristol-Myers Squibb Pharma
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| Structure |
|
Download2D MOL |
|||
| Formula |
C27H32N4O4
|
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| InChI |
InChI=1S/C27H32N4O4/c1-17(2)14-24(25(32)30-34)31-13-12-27(28,26(31)33)20-8-10-21(11-9-20)35-16-19-15-18(3)29-23-7-5-4-6-22(19)23/h4-11,15,17,24,34H,12-14,16,28H2,1-3H3,(H,30,32)/t24-,27-/m1/s1
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| InChIKey |
QVNZBDLTUKCPGJ-SHQCIBLASA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | ADAM 17 | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Notch signaling pathway | ||||
| Alzheimer's disease | |||||
| Epithelial cell signaling in Helicobacter pylori infection | |||||
| PANTHER Pathway | Alzheimer disease-amyloid secretase pathway | ||||
| Alzheimer disease-presenilin pathway | |||||
| Notch signaling pathway | |||||
| Pathway Interaction Database | ErbB4 signaling events | ||||
| TNF receptor signaling pathway | |||||
| p75(NTR)-mediated signaling | |||||
| Reactome | Nuclear signaling by ERBB4 | ||||
| Collagen degradation | |||||
| Regulated proteolysis of p75NTR | |||||
| Activated NOTCH1 Transmits Signal to the Nucleus | |||||
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | |||||
| Constitutive Signaling by NOTCH1 t(7 | |||||
| M1580_K2555) Translocation Mutant | |||||
| Constitutive Signaling by NOTCH1 HD Domain Mutants | |||||
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |||||
| TNF signaling | |||||
| Growth hormone receptor signaling | |||||
| WikiPathways | Notch Signaling Pathway | ||||
| Copper homeostasis | |||||
| Notch Signaling Pathway | |||||
| Growth hormone receptor signaling | |||||
| BDNF signaling pathway | |||||
| Alzheimers Disease | |||||
| Signalling by NGF | |||||
| Extrinsic Pathway for Apoptosis | |||||
| References | |||||
| REF 1 | Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91. | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6509). | ||||
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