Drug General Information
Drug ID	D01BCK
Former ID	DNC013435
Drug Name	N-hydroxy-1-naphthamide
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528719]
Structure		Download 2D MOL 3D MOL
Formula	C11H9NO2
Canonical SMILES	C1=CC=C2C(=C1)C=CC=C2C(=O)NO
InChI	1S/C11H9NO2/c13-11(12-14)10-7-3-5-8-4-1-2-6-9(8)10/h1-7,14H,(H,12,13)
InChIKey	JRZGPWOEHDOVMC-UHFFFAOYSA-N
PubChem Compound ID	23382
Target and Pathway
Target(s)	Histone Deacetylase 8	Target Info	Inhibitor	[528719]
KEGG Pathway	Alcoholism
	Viral carcinogenesis
PANTHER Pathway	Wnt signaling pathway
Pathway Interaction Database	Signaling events mediated by HDAC Class I
Reactome	NOTCH1 Intracellular Domain Regulates Transcription
	Constitutive Signaling by NOTCH1 PEST Domain Mutants
	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
	HDACs deacetylate histones
WikiPathways	Integrated Pancreatic Cancer Pathway
	Neural Crest Differentiation
	Cell Cycle
References
Ref 528719	Bioorg Med Chem Lett. 2007 May 15;17(10):2874-8. Epub 2007 Feb 25.Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors.
Ref 528719	Bioorg Med Chem Lett. 2007 May 15;17(10):2874-8. Epub 2007 Feb 25.Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors.

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