Drug Information

Drug General Information
Drug ID
D01AXB
Former ID
DAP000494
Drug Name
Duloxetine
Synonyms
Cymbalta; Yentreve; LY 248686; Cymbalta (TN); Duloxetine (INN); Duloxetine [INN:BAN]; Yentreve (TN); Duloxetine, (+)-isomer; (3S)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine; (3S)-N-methyl-3-(naphthalen-1-yloxy)-3-(2-thienyl)propan-1-amine; (3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine; (S)-Duloxetine; (S)-N-Methyl-gamma-(1-naphthalenyloxy)-2-thiophenepropanamine
Drug Type
Small molecular drug
Indication Depression [ICD9: 311; ICD10:F30-F39] Approved [536306], [539298]
Therapeutic Class
Antidepressants
Company
Eli Lilly
Structure
Download
2D MOL

3D MOL
Formula
C18H19NOS
InChI
InChI=1S/C18H19NOS/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16/h2-10,13,17,19H,11-12H2,1H3/t17-/m0/s1
InChIKey
ZEUITGRIYCTCEM-KRWDZBQOSA-N
CAS Number
CAS 136434-34-9
PubChem Compound ID
60835
PubChem Substance ID
8187086, 14849439, 14873633, 17425390, 26719725, 26757978, 43118173, 46386929, 46507937, 47285864, 47285865, 47731256, 47805543, 49681583, 50064210, 57314139, 79667093, 92308395, 92714465, 96024576, 103343183, 104026883, 104321767, 117535453, 124658786, 124893161, 126624113, 126633258, 126655387, 126670564, 129892280, 134224927, 134337787, 134338555, 135085912, 135650212, 135723690, 136350845, 137001412, 142415452, 151990477, 160831212, 160963822, 162011976, 163094868, 163393050, 164188025, 164188041, 164831613, 172080136
ChEBI ID
ChEBI:31526
SuperDrug ATC ID
N06AX21
Target and Pathway
Target(s) Sodium-dependent serotonin transporter Target Info Inhibitor [536331], [537531]
Sodium-dependent noradrenaline transporter Target Info Inhibitor [536331], [537531]
KEGG Pathway Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway 5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
SIDS Susceptibility Pathways
NRF2 pathway
Synaptic Vesicle Pathway
Serotonin Transporter ActivityWP727:Monoamine Transport
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 536306Emerging treatments for depression. Expert Opin Pharmacother. 2006 Dec;7(17):2323-39.
Ref 539298(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 202).
Ref 536331Multi-target therapeutics: when the whole is greater than the sum of the parts. Drug Discov Today. 2007 Jan;12(1-2):34-42. Epub 2006 Nov 28.
Ref 537531Duloxetine for the treatment of generalized anxiety disorder: a review. Neuropsychiatr Dis Treat. 2009;5:23-31. Epub 2009 Apr 8.

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