Drug General Information
Drug ID
D01ASJ
Former ID
DIB008334
Drug Name
Nalbuphine hydrochloride ER
Synonyms
PW-4142; Nalbuphine hydrochloride ER (oral, pain, TIMERx); Nalbuphine (oral, extended release, Geminex), Penwest; Nalbuphine (oral, extended release, TIMERx), Penwest; Nalbuphine ER (oral, pain, Geminex), Penwest; Nalbuphine ER (oral, pain, TIMERx), Penwest; Nalbuphine hydrochloride (oral, extended release, TIMERx), Penwest; Nalbuphine hydrochloride ER (oral, pain, TIMERx), Penwest
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Phase 3 [521828]
Company
Penwest Pharmaceuticals Co
Structure
Download
2D MOL

3D MOL

Canonical SMILES
O[C@H]1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC<br />6CCC6)c45
InChI
1S/C21H27NO4/c23-14-5-4-13-10-16-21(25)7-6-15(24)19-20(21,17(13)18(14)26-19)8-9-22(16)11-12-2-1-3-12/h4-5,12,15-16,19,23-25H,1-3,6-11H2/t15-,16+,19-,20-,21+/m0/s1
InChIKey
NETZHAKZCGBWSS-CEDHKZHLSA-N
Target and Pathway
Target(s) Mu-type opioid receptor Target Info Modulator
Kappa-type opioid receptor Target Info Modulator
KEGG Pathway Neuroactive ligand-receptor interaction
Estrogen signaling pathway
Morphine addictionhsa04080:Neuroactive ligand-receptor interaction
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin releaseP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Opioid prodynorphin pathway
Pathway Interaction Database IL4-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways TCR Signaling Pathway
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
Opioid Signalling
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signaling
References
Ref 521828ClinicalTrials.gov (NCT00323154) Nalbuphine for the Treatment of Opioid Induced Pruritus in Children. U.S. National Institutes of Health.

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