Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D01APL
|
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| Former ID |
DIB020292
|
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| Drug Name |
lysergol
|
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| Synonyms |
lysergole
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C16H18N2O
|
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| InChI |
InChI=1S/C16H18N2O/c1-18-8-10(9-19)5-13-12-3-2-4-14-16(12)11(7-17-14)6-15(13)18/h2-5,7,10,15,17,19H,6,8-9H2,1H3/t10-,15-/m1/s1
|
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| InChIKey |
BIXJFIJYBLJTMK-MEBBXXQBSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
7837025, 7979835, 8149859, 8161237, 10321383, 11113286, 11335690, 11360929, 11461901, 11466482, 11467602, 11486203, 15114793, 24824134, 29282975, 47216743, 47291095, 47440211, 47662242, 47810715, 47810716, 48035071, 48259195, 48334452, 49698503, 57328820, 75296128, 81093511, 85789344, 85789392, 88783025, 92125494, 99301603, 103158497, 103214383, 103913880, 103927877, 104335888, 117613576, 118048600, 121363165, 124813263, 127522274, 127583727, 134978869, 135650564, 135837847, 137119908, 139428243, 162189587
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| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine 1D receptor | Target Info | Agonist | [2] | |
| 5-hydroxytryptamine 1B receptor | Target Info | Agonist | [3] | ||
| 5-hydroxytryptamine 1E receptor | Target Info | Agonist | [3] | ||
| KEGG Pathway | cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Serotonergic synapsehsa04024:cAMP signaling pathway | |||||
| Serotonergic synapse | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| 5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
| 5HT1 type receptor mediated signaling pathway | |||||
| Reactome | Serotonin receptors | ||||
| G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors | |||||
| G alpha (i) signalling events | |||||
| WikiPathways | Serotonin HTR1 Group and FOS Pathway | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 123). | ||||
| REF 2 | Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta. Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3630-4. | ||||
| REF 3 | Two amino acid differences in the sixth transmembrane domain are partially responsible for the pharmacological differences between the 5-HT1D beta and 5-HT1E 5-hydroxytryptamine receptors. J Neurochem. 1996 Nov;67(5):2096-103. | ||||
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