Drug Information
Drug General Information | |||||
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Drug ID |
D00ZUU
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Former ID |
DIB011022
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Drug Name |
ONO-5334
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Synonyms |
Bone resorption inhibitor (tablet/oral, osteoporosis/osteopenia), Ono; Cathepsin K inhibitor (tablet/oral formulation, osteoporosis/osteopenia), Ono
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Indication | Osteopenia [ICD9: 733.9; ICD10:M85.8] | Discontinued in Phase 2 | [522118] | ||
Company |
Ono Pharmaceutical Co Ltd
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Structure |
Download2D MOL |
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Target and Pathway | |||||
Target(s) | Cathepsin K | Target Info | Inhibitor | [531317], [532506] | |
WikiPathways | RANKL/RANK Signaling Pathway | ||||
Osteoclast Signaling | |||||
References | |||||
Ref 531317 | New approach for osteoporosis treatment: cathepsin K inhibitor, ONO-5334. Clin Calcium. 2011 Jan;21(1):64-9. | ||||
Ref 532506 | Population pharmacokinetic and pharmacodynamic modeling of different formulations of ONO-5334, cathepsin K inhibitor, in Caucasian and Japanese postmenopausal females. J Clin Pharmacol. 2014 Jan;54(1):23-34. |
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