Drug General Information
Drug ID	D00YWZ
Former ID	DNC007461
Drug Name	3-(4-aminophenyl)thieno[3,2-c]pyridin-4-amine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528593]
Structure		Download 2D MOL 3D MOL
Formula	C13H11N3S
Canonical SMILES	C1=CC(=CC=C1C2=CSC3=C2C(=NC=C3)N)N
InChI	1S/C13H11N3S/c14-9-3-1-8(2-4-9)10-7-17-11-5-6-16-13(15)12(10)11/h1-7H,14H2,(H2,15,16)
InChIKey	RSUCBZJSTXEGSF-UHFFFAOYSA-N
PubChem Compound ID	18450753
Target and Pathway
Target(s)	Vascular endothelial growth factor receptor 2	Target Info	Inhibitor	[528593]
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	Cytokine-cytokine receptor interaction
	Endocytosis
	PI3K-Akt signaling pathway
	VEGF signaling pathway
	Focal adhesion
	Proteoglycans in cancer
NetPath Pathway	IL2 Signaling Pathway
PANTHER Pathway	Angiogenesis
	VEGF signaling pathway
Pathway Interaction Database	HIF-2-alpha transcription factor network
	Beta3 integrin cell surface interactions
	Signaling events mediated by TCPTP
	SHP2 signaling
	S1P1 pathway
	VEGF and VEGFR signaling network
	Integrins in angiogenesis
	Signaling events mediated by VEGFR1 and VEGFR2
	Notch-mediated HES/HEY network
Reactome	Neurophilin interactions with VEGF and VEGFR
	VEGF binds to VEGFR leading to receptor dimerization
	Integrin cell surface interactions
	EPHA-mediated growth cone collapse
	VEGFA-VEGFR2 Pathway
	VEGFR2 mediated cell proliferation
WikiPathways	Focal Adhesion
	Nifedipine Activity
	Cardiac Progenitor Differentiation
	Signaling by VEGF
	Angiogenesis
References
Ref 528593	Bioorg Med Chem Lett. 2007 Mar 1;17(5):1246-9. Epub 2006 Dec 9.Thienopyridine urea inhibitors of KDR kinase.
Ref 528593	Bioorg Med Chem Lett. 2007 Mar 1;17(5):1246-9. Epub 2006 Dec 9.Thienopyridine urea inhibitors of KDR kinase.

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