Drug General Information
Drug ID	D00YOW
Former ID	DIB003692
Drug Name	LM-1376
Indication	Asthma [ICD10:J45]		Terminated	[546076]
Company	Laboratorios Menarini SA
Structure		Download 2D MOL 3D MOL
Canonical SMILES	n1c2c(ccc1COc1cc3cc(C(=O)NCCc4ccc(C(=O)O)cc4)ccc3cc1)cc<br />cc2
CAS Number	CAS 177735-97-6
Target and Pathway
Target(s)	Cysteinyl leukotriene receptor 1	Target Info	Modulator	[556264]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
	IL4 Signaling Pathway
	IL3 Signaling Pathway
Pathway Interaction Database	Endothelins
Reactome	Leukotriene receptors
	G alpha (q) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 546076	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006199)
Ref 556264	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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