Drug Information

Drug General Information
Drug ID
D00TUH
Former ID
DNC005955
Drug Name
8-(4-acetylphenyl)-2-morpholin-4-ylchromen-4-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527888]
Structure
Download
2D MOL

3D MOL
Formula
C21H19NO4
Canonical SMILES
CC(=O)C1=CC=C(C=C1)C2=CC=CC3=C2OC(=CC3=O)N4CCOCC4
InChI
1S/C21H19NO4/c1-14(23)15-5-7-16(8-6-15)17-3-2-4-18-19(24)13-20(26-21(17)18)22-9-11-25-12-10-22/h2-8,13H,9-12H2,1H3
InChIKey
OEHLKVQEMZKDOJ-UHFFFAOYSA-N
PubChem Compound ID
11710022
Target and Pathway
Target(s) DNA-dependent protein kinase catalytic subunit Target Info Inhibitor [527888]
KEGG Pathway Non-homologous end-joining
Cell cycle
NetPath Pathway IL1 Signaling Pathway
Pathway Interaction Database DNA-PK pathway in nonhomologous end joining
Coregulation of Androgen receptor activity
Class I PI3K signaling events mediated by Akt
BARD1 signaling events
Reactome Nonhomologous End-Joining (NHEJ)
WikiPathways DNA Damage Response
Non-homologous end joining
FAS pathway and Stress induction of HSP regulation
Cytosolic sensors of pathogen-associated DNA
Retinoblastoma (RB) in Cancer
Prostate Cancer
Double-Strand Break Repair
Cell Cycle
miRNA Regulation of DNA Damage Response
References
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.

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