Drug General Information
Drug ID	D00SAA
Former ID	DNC006426
Drug Name	3-isopropylnaphthalene-1,2-dione
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527986]
Structure		Download 2D MOL 3D MOL
Formula	C13H12O2
Canonical SMILES	CC(C)C1=CC2=CC=CC=C2C(=O)C1=O
InChI	1S/C13H12O2/c1-8(2)11-7-9-5-3-4-6-10(9)12(14)13(11)15/h3-8H,1-2H3
InChIKey	KGCDZSGUSQQVKL-UHFFFAOYSA-N
PubChem Compound ID	14828129
Target and Pathway
Target(s)	M-phase inducer phosphatase 1	Target Info	Inhibitor	[527986]
KEGG Pathway	Cell cycle
	Progesterone-mediated oocyte maturation
	MicroRNAs in cancer
NetPath Pathway	IL4 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database	E2F transcription factor network
	ATR signaling pathway
	Validated targets of C-MYC transcriptional activation
	ATM pathway
Reactome	E2F mediated regulation of DNA replication
	G0 and Early G1
	Polo-like kinase mediated events
	Cyclin B2 mediated events
	Activation of ATR in response to replication stress
	Cyclin E associated events during G1/S transition
	G1/S-Specific Transcription
	Cyclin A/B1 associated events during G2/M transition
	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
	Cyclin A:Cdk2-associated events at S phase entry
WikiPathways	DNA Damage Response
	G1 to S cell cycle control
	S Phase
	ATM Signaling Pathway
	Retinoblastoma (RB) in Cancer
	Prostate Cancer
	Integrated Breast Cancer Pathway
	Integrated Cancer pathway
	Mitotic G1-G1/S phases
	Cell Cycle
	Cell Cycle Checkpoints
	miRNAs involved in DNA damage response
	miRNA Regulation of DNA Damage Response
References
Ref 527986	Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8. Epub 2006 Jan 24.Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases.
Ref 527986	Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8. Epub 2006 Jan 24.Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases.

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