Drug Information

Drug General Information
Drug ID
D00QTU
Former ID
DIB010322
Drug Name
TH-1320
Synonyms
TH-1320; Topoisomerase I modulators (cancer), Threshold Pharmaceuticals; 14-Aminocamptothecin
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Investigative [543672]
Company
Threshold Pharmaceuticals Inc
Structure
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2D MOL

3D MOL
Canonical SMILES
n12c(c3c(C2)c(c2ccccc2n3)CC)c(c2c(c1=O)COC(=O)[C@]2(O)C<br />C)N
Target and Pathway
Target(s) Toposisomerase-1 Target Info Modulator [543672]
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway DNA replication
Pathway Interaction Database Caspase Cascade in Apoptosis
WikiPathways Integrated Pancreatic Cancer Pathway
References
Ref 543672(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2636).
Ref 543672(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2636).

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