Drug Information

Drug General Information
Drug ID
D00QPG
Former ID
DNC010681
Drug Name
3-(4-dimethylamino-benzylidenyl)-2-indolinone
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541238]
Structure
Download
2D MOL

3D MOL
Formula
C17H16N2O
InChI
InChI=1S/C17H16N2O/c1-19(2)13-9-7-12(8-10-13)11-15-14-5-3-4-6-16(14)18-17(15)20/h3-11H,1-2H3,(H,18,20)/b15-11+
InChIKey
UAKWLVYMKBWHMX-RVDMUPIBSA-N
PubChem Compound ID
5353593
PubChem Substance ID
3260435, 11111828, 11114091, 11651337, 12016303, 14799071, 24278803, 26758623, 39379677, 47959545, 50755225, 57361562, 85787124, 89744714, 99302656, 103127946, 103229732, 104006141, 105581615, 113909410, 117597067, 118083769, 130672448, 134588662, 135697959, 137077376, 140704618, 142688955, 163688217, 175607402, 177748525, 178102581, 179148521, 180189441, 226943880, 238391498, 252334293
Target and Pathway
Target(s) Beta platelet-derived growth factor receptor Target Info Inhibitor [530858]
KEGG Pathway MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Focal adhesion
Gap junction
Regulation of actin cytoskeleton
HTLV-I infection
Pathways in cancer
MicroRNAs in cancer
Glioma
Prostate cancer
Melanoma
Central carbon metabolism in cancer
Choline metabolism in cancer
PANTHER Pathway Angiogenesis
PDGF signaling pathway
Pathway Interaction Database Signaling events mediated by PTP1B
Beta3 integrin cell surface interactions
S1P3 pathway
Nectin adhesion pathway
Signaling events mediated by TCPTP
SHP2 signaling
S1P1 pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
PDGFR-beta signaling pathway
Validated targets of C-MYC transcriptional repression
PDGF receptor signaling network
Reactome PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
WikiPathways Regulation of Actin Cytoskeleton
MAPK Signaling Pathway
Osteoblast Signaling
Focal Adhesion
PIP3 activates AKT signaling
PDGF Pathway
Signaling Pathways in Glioblastoma
Signaling by PDGF
References
Ref 541238(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5958).
Ref 530858Bioorg Med Chem. 2010 May 15;18(10):3575-87. Epub 2010 Mar 27.Synthesis and biological activity of N(4)-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.