Drug General Information
Drug ID
D00QFY
Former ID
DNCL003336
Drug Name
YM533
Synonyms
Beraprost sodium
Drug Type
Small molecular drug
Indication Chronic renal failure [ICD9: 585.9585.1-585.5403; ICD10:N18] Discontinued in Phase 3 [548502]
Company
Astellas
Structure
Download
2D MOL

3D MOL

Formula
C24H29NaO5
Canonical SMILES
CC#CCC(C)C(C=CC1C(CC2C1C3=C(O2)C(=CC=C3)CCCC(=O)[O-])O)<br />O.[Na+]
InChI
1S/C24H30O5.Na/c1-3-4-7-15(2)19(25)13-12-17-20(26)14-21-23(17)18-10-5-8-16(24(18)29-21)9-6-11-22(27)28;/h5,8,10,12-13,15,17,19-21,23,25-26H,6-7,9,11,14H2,1-2H3,(H,27,28);/q;+1/p-1/b13-12+;
InChIKey
YTCZZXIRLARSET-UEIGIMKUSA-M
PubChem Compound ID
PubChem Substance ID
SuperDrug ATC ID
B01AC19
Target and Pathway
Target(s) Prostacyclin receptor Target Info Modulator [543782]
KEGG Pathway Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Platelet activation
Pathway Interaction Database Thromboxane A2 receptor signaling
PathWhiz Pathway Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin
Reactome Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
Endothelin Pathways
Platelet homeostasis
GPCR ligand binding
GPCR downstream signaling
References
Ref 548502Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026064)
Ref 543782(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 345).

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