Drug Information

Drug General Information
Drug ID
D00QDE
Former ID
DNC007968
Drug Name
7-bromo-6H-chromeno[4,3-b]quinoline-3,9-diol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528822]
Structure
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2D MOL

3D MOL
Formula
C16H10BrNO3
Canonical SMILES
C1C2=C(C3=C(C=CC(=C3)O)NC2=C4C=CC(=O)C=C4O1)Br
InChI
1S/C16H10BrNO3/c17-15-11-5-8(19)2-4-13(11)18-16-10-3-1-9(20)6-14(10)21-7-12(15)16/h1-6,18-19H,7H2
InChIKey
XVNHJGZNGDSCON-UHFFFAOYSA-N
PubChem Compound ID
11559247
Target and Pathway
Target(s) Steroid hormone receptor ERR1 Target Info Inhibitor [528822]
Reactome PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Nuclear Receptor transcription pathway
WikiPathways Mitochondrial Gene Expression
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Nuclear Receptors
References
Ref 528822Bioorg Med Chem Lett. 2007 Jul 15;17(14):4053-6. Epub 2007 May 4.ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands.
Ref 528822Bioorg Med Chem Lett. 2007 Jul 15;17(14):4053-6. Epub 2007 May 4.ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands.

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