Drug Information
Drug General Information | |||||
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Drug ID |
D00PEN
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Drug Name |
MGD007
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Drug Type |
Monoclonal antibody
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Indication | Colorectal cancer [ICD9: 153, 154; ICD10:C18-C21] | Phase 1 | [889404] | ||
Company |
MacroGenics
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Target and Pathway | |||||
Target(s) | CD3 | Target Info | Modulator | [889442] | |
Cell surface A33 antigen | Target Info | Modulator | [889442] | ||
NetPath Pathway | TCR Signaling Pathway | ||||
PANTHER Pathway | T cell activation | ||||
Reactome | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | ||||
Phosphorylation of CD3 and TCR zeta chains | |||||
Translocation of ZAP-70 to Immunological synapse | |||||
Generation of second messenger molecules | |||||
FCGR activation | |||||
Regulation of actin dynamics for phagocytic cup formation | |||||
Role of phospholipids in phagocytosis | |||||
PD-1 signaling | |||||
References |
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