Drug Information

Drug General Information
Drug ID
D00NWF
Former ID
DNC005107
Drug Name
ZM-336372
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529039]
Structure
Download
2D MOL

3D MOL
Formula
C23H23N3O3
Canonical SMILES
CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)N(C)C)NC(=O)C3=CC=C(C<br />=C3)O
InChI
1S/C23H23N3O3/c1-15-7-10-18(24-23(29)17-5-4-6-19(13-17)26(2)3)14-21(15)25-22(28)16-8-11-20(27)12-9-16/h4-14,27H,1-3H3,(H,24,29)(H,25,28)
InChIKey
PYEFPDQFAZNXLI-UHFFFAOYSA-N
PubChem Compound ID
5730
Target and Pathway
Target(s) Lck tyrosine kinase Target Info Inhibitor [529039]
Mitogen-activated protein kinase 14 Target Info Inhibitor [527229]
mRNA of RAF proto-oncogene serine/threonine-protein kinase Target Info Inhibitor [529039]
mRNA of B-Raf Target Info Inhibitor [529039]
BioCyc Pathway MAP kinase cascade
KEGG Pathway NF-kappa B signaling pathway
Osteoclast differentiation
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
HTLV-I infection
Primary immunodeficiencyhsa04010:MAPK signaling pathway
Rap1 signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Fc epsilon RI signaling pathway
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Retrograde endocannabinoid signaling
Dopaminergic synapse
Inflammatory mediator regulation of TRP channels
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Prolactin signaling pathway
Amyotrophic lateral sclerosis (ALS)
Epithelial cell signaling in Helicobacter pylori infection
Shigellosis
Salmonella infection
Pertussis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Influenza A
Epstein-Barr virus infection
Proteoglycans in cancerhsa04010:MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
PI3K-Akt signaling pathway
Vascular smooth muscle contraction
Focal adhesion
Gap junction
B cell receptor signaling pathway
Fc gamma R-mediated phagocytosis
Long-term potentiation
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Alcoholism
Hepatitis B
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Central carbon metabolism in cancer
Choline metabolism in cancerhsa04010:MAPK signaling pathway
mTOR signaling pathway
Thyroid cancer
NetPath Pathway TCR Signaling Pathway
IL2 Signaling PathwayNetPath_17:IL5 Signaling Pathway
FSH Signaling Pathway
TCR Signaling PathwayNetPath_17:IL5 Signaling Pathway
IL2 Signaling Pathway
EGFR1 Signaling PathwayNetPath_19:IL-7 Signaling Pathway
PANTHER Pathway Parkinson disease
T cell activationP00003:Alzheimer disease-amyloid secretase pathway
Angiogenesis
B cell activation
EGF receptor signaling pathway
FGF signaling pathway
Interferon-gamma signaling pathway
Oxidative stress response
TGF-beta signaling pathway
Toll receptor signaling pathway
VEGF signaling pathway
Ras Pathway
p53 pathway feedback loops 2
p38 MAPK pathway
CCKR signaling map STP00005:Angiogenesis
Endothelin signaling pathway
Inflammation mediated by chemokine and cytokine signaling pathway
Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
Integrin signalling pathway
Interleukin signaling pathway
PDGF signaling pathway
T cell activation
Angiotensin II-stimulated signaling through G proteins and beta-arrestin
CCKR signaling map ST
Pathway Interaction Database Atypical NF-kappaB pathway
Glypican 1 network
TCR signaling in na&#xef
Signaling events mediated by PTP1B
IL12-mediated signaling events
Regulation of p38-alpha and p38-beta
TCR signaling in na&#xef
Thromboxane A2 receptor signaling
SHP2 signaling
IL2-mediated signaling events
CXCR4-mediated signaling events
Class I PI3K signaling events
IL2 signaling events mediated by PI3K
amb2 Integrin signaling
EPHA forward signaling
PDGFR-beta signaling pathway
IL2 signaling events mediated by STAT5
Ephrin B reverse signaling
Alpha-synuclein signalingendothelinpathway:Endothelins
BCR signaling pathway
p73 transcription factor network
p38 MAPK signaling pathway
IL4-mediated signaling events
CD40/CD40L signaling
CDC42 signaling events
Angiopoietin receptor Tie2-mediated signaling
FAS (CD95) signaling pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Glucocorticoid receptor regulatory network
Rapid glucocorticoid signaling
Regulation of Androgen receptor activity
ATF-2 transcription factor network
IL6-mediated signaling events
p38 signaling mediated by MAPKAP kinases
Retinoic acid receptors-mediated signaling
CXCR3-mediated signaling events
Signaling mediated by p38-alpha and p38-beta
EPO signaling pathway
Signaling events mediated by VEGFR1 and VEGFR2
p53 pathway
S1P2 pathway
Trk receptor signaling mediated by the MAPK pathway
VEGFR3 signaling in lymphatic endothelium
FGF signaling pathway
RAC1 signaling pathway
Regulation of retinoblastoma proteinfcer1pathway:Fc-epsilon receptor I signaling in mast cells
Endothelins
GMCSF-mediated signaling events
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
mTOR signaling pathway
IGF1 pathway
Ras signaling in the CD4+ TCR pathway
Ceramide signaling pathway
ErbB1 downstream signaling
ErbB2/ErbB3 signaling events
Nongenotropic Androgen signaling
Internalization of ErbB1
Signaling events mediated by Stem cell factor receptor (c-Kit)
Class I PI3K signaling events mediated by Akt
Downstream signaling in na&#xef
Regulation of retinoblastoma protein
Signaling events mediated by focal adhesion kinasecdc42_pathway:CDC42 signaling events
PathWhiz Pathway Fc Epsilon Receptor I Signaling in Mast CellsPW000453:Fc Epsilon Receptor I Signaling in Mast Cells
Insulin SignallingPW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome GPVI-mediated activation cascade
PIP3 activates AKT signaling
Regulation of KIT signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
PECAM1 interactions
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CTLA4 inhibitory signaling
PD-1 signaling
Interleukin-2 signalingR-HSA-168638:NOD1/2 Signaling Pathway
p38MAPK events
ERK/MAPK targets
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Oxidative Stress Induced Senescence
CDO in myogenesis
DSCAM interactions
ADP signalling through P2Y purinoceptor 1
Platelet sensitization by LDL
VEGFA-VEGFR2 Pathway
activated TAK1 mediates p38 MAPK activation
Activation of the AP-1 family of transcription factors
KSRP (KHSRP) binds and destabilizes mRNAR-HSA-2672351:Stimuli-sensing channels
GP1b-IX-V activation signalling
CREB phosphorylation through the activation of Ras
CD209 (DC-SIGN) signaling
RAF activation
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathwayR-HSA-1295596:Spry regulation of FGF signaling
Frs2-mediated activation
ARMS-mediated activation
Negative regulation of MAPK pathway
WikiPathways Notch Signaling Pathway
Interferon type I signaling pathways
IL-2 Signaling Pathway
Inflammatory Response Pathway
Signaling by SCF-KIT
DAP12 interactions
Host Interactions of HIV factors
PIP3 activates AKT signaling
T-Cell Receptor and Co-stimulatory Signaling
B Cell Receptor Signaling Pathway
TSLP Signaling Pathway
TCR signaling
Costimulation by the CD28 familyWP75:Toll-like receptor signaling pathway
Monoamine Transport
Serotonin HTR1 Group and FOS Pathway
TCR Signaling Pathway
Senescence and Autophagy in Cancer
Insulin Signaling
EGF/EGFR Signaling Pathway
MAPK Cascade
Oxidative Stress
p38 MAPK Signaling Pathway
IL-4 Signaling Pathway
MAPK Signaling Pathway
TGF beta Signaling Pathway
Kit receptor signaling pathway
Cardiac Hypertrophic Response
MAP kinase activation in TLR cascade
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
Nanoparticle-mediated activation of receptor signaling
Structural Pathway of Interleukin 1 (IL-1)
JAK/STAT
Amyotrophic lateral sclerosis (ALS)
Alpha 6 Beta 4 signaling pathway
Cardiac Progenitor Differentiation
BDNF signaling pathway
Integrated Pancreatic Cancer Pathway
Oncostatin M Signaling Pathway
Parkinsons Disease Pathway
Corticotropin-releasing hormone
AGE/RAGE pathway
Prostate Cancer
TWEAK Signaling Pathway
FSH signaling pathway
Leptin signaling pathway
RANKL/RANK Signaling Pathway
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBase
IL-1 signaling pathway
Signal amplification
Platelet homeostasis
NGF signalling via TRKA from the plasma membrane
Myogenesis
DSCAM interactions
MicroRNAs in cardiomyocyte hypertrophy
Angiogenesis
Physiological and Pathological Hypertrophy of the Heart
Regulation of toll-like receptor signaling pathwayWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
EPO Receptor Signaling
Regulation of Actin Cytoskeleton
Signaling of Hepatocyte Growth Factor Receptor
Extracellular vesicle-mediated signaling in recipient cells
IL-3 Signaling Pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
RAF/MAP kinase cascade
Iron uptake and transport
PDGF Pathway
Retinoblastoma (RB) in Cancer
Interleukin-11 Signaling Pathway
TNF alpha Signaling Pathway
Signaling Pathways in Glioblastoma
Endothelin Pathways
Rap1 signalling
Integrin-mediated Cell Adhesion
GP1b-IX-V activation signalling
IL-5 Signaling PathwayWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
Bladder Cancer
Polycystic Kidney Disease Pathway
Integrated Breast Cancer Pathway
Signaling by FGFR
References
Ref 529039Biochem J. 2007 Dec 15;408(3):297-315.The selectivity of protein kinase inhibitors: a further update.
Ref 527229Bioorg Med Chem Lett. 2004 Nov 1;14(21):5383-7.A novel series of p38 MAP kinase inhibitors for the potential treatment of rheumatoid arthritis.
Ref 529039Biochem J. 2007 Dec 15;408(3):297-315.The selectivity of protein kinase inhibitors: a further update.

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