Drug Information

Drug General Information
Drug ID
D00NPE
Former ID
DIB007279
Drug Name
MMP-408
Synonyms
MMP-118; MMP-145; MMP-408; MMP-12 inhibitors (COPD); MMP-12 inhibitors (COPD), Pfizer; MMP-12 inhibitors (COPD), Wyeth
Indication Asthma; Chronic obstructive pulmonary disease [ICD9: 490-492, 493, 494-496; ICD10:J40-J44, J47, J45] Investigative [543453]
Company
Wyeth
Structure
Download
2D MOL

3D MOL
Canonical SMILES
O=S(=O)(c1ccc2c3cc(ccc3oc2c1)c1sccn1)NC(C(=O)O)C(C)C
Target and Pathway
Target(s) MMP-12 Target Info Inhibitor [543453]
NetPath Pathway IL1 Signaling Pathway
IL5 Signaling Pathway
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
WikiPathways TGF beta Signaling Pathway
Degradation of collagen
Matrix Metalloproteinases
References
Ref 543453(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1636).
Ref 543453(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1636).

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.