Drug General Information
Drug ID
D00LWS
Former ID
DIB015773
Drug Name
Ataprost
Synonyms
ONO-41483; OP-41483
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Discontinued in Phase 3 [545086]
Company
Ono Pharmaceutical Co Ltd
Structure
Download
2D MOL

3D MOL

Formula
C21H32O4
Canonical SMILES
[C@H]12[C@H](C[C@H]([C@@H]1/C=C/[C@H](C1CCCC1)O)O)C/C(=<br />C\CCCC(=O)O)/C2
CAS Number
CAS 83997-19-7
PubChem Compound ID
Target and Pathway
Target(s) Prostacyclin receptor Target Info Modulator [533933]
KEGG Pathway Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Platelet activation
Pathway Interaction Database Thromboxane A2 receptor signaling
PathWhiz Pathway Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin
Reactome Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
Endothelin Pathways
Platelet homeostasis
GPCR ligand binding
GPCR downstream signaling
References
Ref 545086Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002073)
Ref 533933Pharmacokinetics of intravenous ataprost alfadex, a new prostaglandin I2 analog in healthy volunteers. Int J Clin Pharmacol Ther Toxicol. 1993 Aug;31(8):373-5.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.