| Drug General Information |
| Drug ID |
D00JTE
|
| Former ID |
DNC009866
|
| Drug Name |
1,1-diphenyl-2-(3-tropanyl)ethanol
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C22H27NO
|
| Canonical SMILES |
CN1C2CCC1CC(C2)CC(C3=CC=CC=C3)(C4=CC=CC=C4)O
|
| InChI |
1S/C22H27NO/c1-23-20-12-13-21(23)15-17(14-20)16-22(24,18-8-4-2-5-9-18)19-10-6-3-7-11-19/h2-11,17,20-21,24H,12-16H2,1H3/t20-,21-/m1/s1
|
| InChIKey |
LAOBIJDCKIAALB-NHCUHLMSSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
|
| Target and Pathway |
| Target(s) |
Muscarinic acetylcholine receptor M1 |
Target Info |
Inhibitor |
[1]
|
|---|
| Muscarinic acetylcholine receptor M2 |
Target Info |
Inhibitor |
[1]
|
| Muscarinic acetylcholine receptor M3 |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
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Calcium signaling pathway
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|
cAMP signaling pathway
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Neuroactive ligand-receptor interaction
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PI3K-Akt signaling pathway
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Cholinergic synapse
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Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
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Regulation of actin cytoskeleton
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Insulin secretion
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Salivary secretion
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Gastric acid secretion
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Pancreatic secretion
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PANTHER Pathway
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Alzheimer disease-amyloid secretase pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Muscarinic acetylcholine receptor 2 and 4 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
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Muscarinic acetylcholine receptor 1 and 3 signaling pathway
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PathWhiz Pathway
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Muscle/Heart ContractionPW000565:Gastric Acid Production
|
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Reactome
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Muscarinic acetylcholine receptors
|
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G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
|
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G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
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Acetylcholine regulates insulin secretion
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G alpha (q) signalling events
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WikiPathways
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Monoamine GPCRs
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Calcium Regulation in the Cardiac Cell
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Regulation of Actin Cytoskeleton
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GPCRs, Class A Rhodopsin-like
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Gastrin-CREB signalling pathway via PKC and MAPK
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Secretion of Hydrochloric Acid in Parietal Cells
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GPCR ligand binding
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GPCR downstream signalingWP706:SIDS Susceptibility Pathways
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GPCR downstream signaling
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GPCRs, OtherWP58:Monoamine GPCRs
|
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Integration of energy metabolism
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GPCRs, Other
|
| References |
| REF 1 | Bioorg Med Chem Lett. 2009 Aug 15;19(16):4560-2. Epub 2009 Jul 8.Discovery of (3-endo)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide as an efficacious inhaled muscarinic acetylcholine receptor antagonist for the treatment of COPD. |
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