Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D00JSG
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| Former ID |
DIB010689
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| Drug Name |
Fluoratec
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| Synonyms |
Technepine; DAT imaging agent, Alseres; DAT imaging agent, Boston life Sciences; DAT imaging agent, Harvard University; Dopamine transporter imaging agent, Alseres; Dopamine transporter imaging agent, Boston life Sciences; O-1505; O-1505T; O-1506; O-1730; O-1783; O-1794; O-861T; Dopamine transporter imaging agent, Harvard/MIT/Organix; 99mTc-O-1505; 99mTc-O-1505T
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| Indication | Attention deficit hyperactivity disorder [ICD9: 314; ICD10:F90] | Terminated | [1] | ||
| Company |
Harvard University
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
N(CC(=O)[N-]CC[S-])(CC[S-])CCCN1[C@H]2[C@H]([C@@H](C[C@<br/>@H]1CC2)c1ccc(cc1)F)C(=O)CC.[99Tc+3]=O
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| Target and Pathway | |||||
| Target(s) | Sodium-dependent dopamine transporter | Target Info | Modulator | [2] | |
| KEGG Pathway | Dopaminergic synapse | ||||
| Parkinson's disease | |||||
| Cocaine addiction | |||||
| Amphetamine addiction | |||||
| Alcoholism | |||||
| PANTHER Pathway | Adrenaline and noradrenaline biosynthesis | ||||
| Parkinson disease | |||||
| Dopamine receptor mediated signaling pathway | |||||
| Pathway Interaction Database | Alpha-synuclein signaling | ||||
| Reactome | Na+/Cl- dependent neurotransmitter transporters | ||||
| WikiPathways | Monoamine Transport | ||||
| NRF2 pathway | |||||
| Dopaminergic Neurogenesis | |||||
| Parkinsons Disease Pathway | |||||
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | |||||
| Neurotransmitter Clearance In The Synaptic Cleft | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016245) | ||||
| REF 2 | Technepine: a high-affinity 99m-technetium probe to label the dopamine transporter in brain by SPECT imaging. Synapse. 1996 Mar;22(3):239-46. | ||||
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