Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D00IWL
|
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| Former ID |
DIB009029
|
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| Drug Name |
PolyHeme
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| Synonyms |
Oxygen-carrying blood substitute, Northfield Laboratories
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| Indication | Blood forming organ disorders [ICD10:D75.9] | Phase 3 | [1] | ||
| Company |
Northfield Laboratories
|
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| Structure |
|
Download2D MOL |
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| Target and Pathway | |||||
| Target(s) | Hemoglobin | Target Info | Modulator | [2] | |
| KEGG Pathway | African trypanosomiasis | ||||
| Malaria | |||||
| Reactome | Erythrocytes take up carbon dioxide and release oxygen | ||||
| Erythrocytes take up oxygen and release carbon dioxide | |||||
| Scavenging of heme from plasma | |||||
| WikiPathways | Binding and Uptake of Ligands by Scavenger Receptors | ||||
| Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes | |||||
| Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes | |||||
| Factors involved in megakaryocyte development and platelet production | |||||
| Folate Metabolism | |||||
| Vitamin B12 Metabolism | |||||
| Selenium Micronutrient Network | |||||
| References | |||||
| REF 1 | ClinicalTrials.gov (NCT00076648) Safety and Efficacy of PolyHeme(R) in Hemorrhagic Shock Following Traumatic Injuries Beginning in the Pre-Hospital Setting. U.S. National Institutes of Health. | ||||
| REF 2 | Blood substitutes- the polyheme trials. Mcgill J Med. 2008 January; 11(1): 59-65. | ||||
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