Drug Information

Drug General Information
Drug ID
D00HHS
Former ID
DAP000195
Drug Name
Pseudoephedrine
Synonyms
Acunaso; Afrinol; Besan; Cenafed; Decofed; Ephedrine; Genaphed; Isoephedrine; Maxenal; Myfedrine; Neodurasina; Pseudo; Pseudoefedrina; Pseudoephedrinum; Robidrine; Sudafed; Balminil Decongestant Syrup; Benylin Decongestant; Dimetapp Decongestant; Dimetapp Decongestant Pediatric Drops; Drixoral Nasal Decongestant; Pedia Care; Pseudoephedrine Ephedrine; Sudafed Decongestant; Sudafed Decongestant Extra Strength; Triaminic AM Decongestant Formula; Triaminic Infant Oral Decongestant Drops; Efidac 24 PseudoephedrineHcl; Eltor 120; Sudafed Decongestant 12 Hour; Actifed (TN); Acunaso (TN); D-Isoephedrine; D-Pseudoephedrine; Efidac/24; Neodurasina (TN); Pseudo 60's; Pseudo-12; Pseudoefedrina [INN-Spanish]; Pseudoephedrine (D); Pseudoephedrine (INN); Pseudoephedrine [INN:BAN]; Pseudoephedrine d-form; Pseudoephedrinum [INN-Latin]; Psi-ephedrin; Psi-ephedrine; Sudafed (TN); Trans-Ephedrine; Claritin-D (TN); D-psi-Ephedrine; Drixoral N.D.; Alpha-(1-(Methylamino)ethyl)benzyl alcohol; L(+)-psi-Ephedrine; L-(+)-Pseudoephedrine; D-psi-2-Methylamino-1-phenyl-1-propanol; Benzenemethanol, alpha-((1S)-1-(methylamino)ethyl)-, (alpha-S)-(9CI); (+)-(1S,2S)-Pseudoephedrine; (+)-Pseudoephedrine; (+)-psi-Ephedrine; (+)-threo-Ephedrine; (1S,2S)-(+)-Pseudoephedrine; (1S,2S)-2-(methylamino)-1-phenylpropan-1-ol; (1S,2S)-2-Methylamino-1-phenyl-1-propanol; (1S,2S)-Pseudoephedrine; (1S,2S)-Pseudoephedrine, polymer-bound; 649031_ALDRICH
Drug Type
Small molecular drug
Indication Nasal congestion [ICD9: 478.19; ICD10:J34.89] Approved [538291], [542306]
Company
Pfizer Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C10H15NO
InChI
InChI=1S/C10H15NO/c1-8(11-2)10(12)9-6-4-3-5-7-9/h3-8,10-12H,1-2H3/t8-,10+/m0/s1
InChIKey
KWGRBVOPPLSCSI-WCBMZHEXSA-N
CAS Number
CAS 90-82-4
PubChem Compound ID
7028
PubChem Substance ID
5721, 605289, 7980426, 8154627, 11111142, 11335626, 11360865, 11363772, 11366334, 11368896, 11372860, 11374901, 11377058, 11407347, 11461837, 11485101, 11489119, 11491586, 11492976, 11494692, 15120370, 24857282, 24883628, 29225939, 46508190, 47589216, 47736742, 47885640, 48334767, 48416496, 50026888, 50122789, 56464196, 57391157, 79710053, 85788938, 92718094, 93166975, 93623258, 96025135, 103590224, 104224960, 104313759, 126524245, 126628590, 126687543, 128443808, 134222123, 134337514, 134971121
ChEBI ID
ChEBI:51209
SuperDrug ATC ID
R01BA02
SuperDrug CAS ID
cas=000090824
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Stimulator [535332], [537761]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 538291FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 075153.
Ref 542306(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7286).
Ref 535332Cetirizine/pseudoephedrine. Drugs. 2001;61(15):2231-40; discussion 2241-2.
Ref 537761Drugs for cough and cold symptoms in hypertensive patients. Am Fam Physician. 1985 Mar;31(3):183-7.

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