Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D00HHS
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| Former ID |
DAP000195
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| Drug Name |
Pseudoephedrine
|
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| Synonyms |
Acunaso; Afrinol; Besan; Cenafed; Decofed; Ephedrine; Genaphed; Isoephedrine; Maxenal; Myfedrine; Neodurasina; Pseudo; Pseudoefedrina; Pseudoephedrinum; Robidrine; Sudafed; Balminil Decongestant Syrup; Benylin Decongestant; Dimetapp Decongestant; Dimetapp Decongestant Pediatric Drops; Drixoral Nasal Decongestant; Pedia Care; Pseudoephedrine Ephedrine; Sudafed Decongestant; Sudafed Decongestant Extra Strength; Triaminic AM Decongestant Formula; Triaminic Infant Oral Decongestant Drops; Efidac 24 PseudoephedrineHcl; Eltor 120; Sudafed Decongestant 12 Hour; Actifed (TN); Acunaso (TN); D-Isoephedrine; D-Pseudoephedrine; Efidac/24; Neodurasina (TN); Pseudo 60's; Pseudo-12; Pseudoefedrina [INN-Spanish]; Pseudoephedrine (D); Pseudoephedrine (INN); Pseudoephedrine [INN:BAN]; Pseudoephedrine d-form; Pseudoephedrinum [INN-Latin]; Psi-ephedrin; Psi-ephedrine; Sudafed (TN); Trans-Ephedrine; Claritin-D (TN); D-psi-Ephedrine; Drixoral N.D.; Alpha-(1-(Methylamino)ethyl)benzyl alcohol; L(+)-psi-Ephedrine; L-(+)-Pseudoephedrine; D-psi-2-Methylamino-1-phenyl-1-propanol; Benzenemethanol, alpha-((1S)-1-(methylamino)ethyl)-, (alpha-S)-(9CI); (+)-(1S,2S)-Pseudoephedrine; (+)-Pseudoephedrine; (+)-psi-Ephedrine; (+)-threo-Ephedrine; (1S,2S)-(+)-Pseudoephedrine; (1S,2S)-2-(methylamino)-1-phenylpropan-1-ol; (1S,2S)-2-Methylamino-1-phenyl-1-propanol; (1S,2S)-Pseudoephedrine; (1S,2S)-Pseudoephedrine, polymer-bound; 649031_ALDRICH
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| Drug Type |
Small molecular drug
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| Indication | Nasal congestion [ICD9: 478.19; ICD10:J34.89] | Approved | [1], [2] | ||
| Company |
Pfizer Pharmaceuticals
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| Structure |
|
Download2D MOL |
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| Formula |
C10H15NO
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| InChI |
InChI=1S/C10H15NO/c1-8(11-2)10(12)9-6-4-3-5-7-9/h3-8,10-12H,1-2H3/t8-,10+/m0/s1
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| InChIKey |
KWGRBVOPPLSCSI-WCBMZHEXSA-N
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| CAS Number |
CAS 90-82-4
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| PubChem Compound ID | |||||
| PubChem Substance ID |
5721, 605289, 7980426, 8154627, 11111142, 11335626, 11360865, 11363772, 11366334, 11368896, 11372860, 11374901, 11377058, 11407347, 11461837, 11485101, 11489119, 11491586, 11492976, 11494692, 15120370, 24857282, 24883628, 29225939, 46508190, 47589216, 47736742, 47885640, 48334767, 48416496, 50026888, 50122789, 56464196, 57391157, 79710053, 85788938, 92718094, 93166975, 93623258, 96025135, 103590224, 104224960, 104313759, 126524245, 126628590, 126687543, 128443808, 134222123, 134337514, 134971121
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| ChEBI ID |
ChEBI:51209
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| SuperDrug ATC ID |
R01BA02
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| SuperDrug CAS ID |
cas=000090824
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| Target and Pathway | |||||
| Target(s) | D(2) dopamine receptor | Target Info | Stimulator | [3], [4] | |
| KEGG Pathway | Rap1 signaling pathway | ||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Gap junction | |||||
| Dopaminergic synapse | |||||
| Parkinson's disease | |||||
| Cocaine addiction | |||||
| Alcoholism | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Dopamine receptor mediated signaling pathway | |||||
| Nicotine pharmacodynamics pathway | |||||
| Reactome | Dopamine receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | Hypothetical Network for Drug Addiction | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Genes and (Common) Pathways Underlying Drug Addiction | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| Nicotine Activity on Dopaminergic Neurons | |||||
| References | |||||
| REF 1 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 075153. | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7286). | ||||
| REF 3 | Cetirizine/pseudoephedrine. Drugs. 2001;61(15):2231-40; discussion 2241-2. | ||||
| REF 4 | Drugs for cough and cold symptoms in hypertensive patients. Am Fam Physician. 1985 Mar;31(3):183-7. | ||||
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