Drug General Information
Drug ID	D00HFD
Former ID	DIB005674
Drug Name	E-6080
Drug Type	Small molecular drug
Indication	Asthma [ICD10:J45]		Discontinued in Phase 2	[545041]
Company	Eisai Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C17H20ClN3O3S2
Canonical SMILES	c12c(c(c(c(c2C)C)O)C)sc(n1)NCc1ccc(S(=O)(=O)N)cc1.Cl
CAS Number	CAS 120164-49-0
PubChem Compound ID	129064
Target and Pathway
Target(s)	Arachidonate 5-lipoxygenase	Target Info	Inhibitor	[526797]
BioCyc Pathway	Aspirin-triggered lipoxin biosynthesis
	Resolvin D biosynthesis
	Leukotriene biosynthesis
	Lipoxin biosynthesis
	Aspirin triggered resolvin D biosynthesis
	Aspirin triggered resolvin E biosynthesis
KEGG Pathway	Arachidonic acid metabolism
	Metabolic pathways
	Serotonergic synapse
	Ovarian steroidogenesis
	Toxoplasmosis
NetPath Pathway	IL4 Signaling Pathway
PathWhiz Pathway	Arachidonic Acid Metabolism
WikiPathways	Vitamin D Receptor Pathway
	Arachidonic acid metabolism
	Eicosanoid Synthesis
	Selenium Micronutrient Network
References
Ref 545041	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001952)
Ref 526797	Effects of the new 5-lipoxygenase inhibitor E6080 on leukotriene release in vitro. Int Arch Allergy Immunol. 1992;97(4):267-73.

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