Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D00FHI
|
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| Former ID |
DIB002014
|
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| Drug Name |
Zabiciprilat
|
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| Synonyms |
Zabicipril; S-10211; S-9650
|
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| Drug Type |
Small molecular drug
|
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| Indication | Hypertension [ICD9: 401; ICD10:I10-I16] | Discontinued in Phase 2 | [1] | ||
| Company |
Servier
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C21H28N2O5
|
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| Canonical SMILES |
N1(C(=O)[C@@H](N[C@H](C(=O)O)CCc2ccccc2)C)[C@H](C(=O)O)<br />C2CCC1CC2
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Angiotensin-converting enzyme | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Renin-angiotensin system | ||||
| Chagas disease (American trypanosomiasis) | |||||
| Hypertrophic cardiomyopathy (HCM) | |||||
| PathWhiz Pathway | Angiotensin Metabolism | ||||
| Reactome | Metabolism of Angiotensinogen to Angiotensins | ||||
| WikiPathways | ACE Inhibitor Pathway | ||||
| Metabolism of Angiotensinogen to Angiotensins | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000139) | ||||
| REF 2 | Enzyme immunoassays for a new angiotensin-converting enzyme inhibitor, zabicipril, and its active metabolite in human plasma: application to pharmacokinetic studies. Ther Drug Monit. 1993 Oct;15(5):448-54. | ||||
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