Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D00EZE
|
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| Former ID |
DIB004442
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| Drug Name |
Panamesine
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| Synonyms |
EMD-57445; EMD-59983
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| Drug Type |
Small molecular drug
|
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| Indication | Psychotic disorders [ICD9: 290-299; ICD10:F20-F29] | Discontinued in Phase 2 | [1] | ||
| Company |
Merck KGaA
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| Structure |
|
Download2D MOL |
|||
| Formula |
C23H26N2O6
|
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| Canonical SMILES |
C1(=O)N(C[C@@H](O1)CN1CCC(c2cc3c(OCO3)cc2)(CC1)O)c1ccc(<br />cc1)OC
|
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| CAS Number |
CAS 139225-22-2
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Sigma(1)-type opioid receptor | Target Info | Binder | [2], [3], [4] | |
| WikiPathways | miR-targeted genes in squamous cell - TarBase | ||||
| miR-targeted genes in lymphocytes - TarBase | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001428) | ||||
| REF 2 | Efficacy and safety of the sigma receptor ligand EMD 57445 (panamesine) in patients with schizophrenia: an open clinical trial. Pharmacopsychiatry. 1999 Mar;32(2):68-72. | ||||
| REF 3 | Dextromethorphan antagonizes the acute depletion of brain serotonin by p-chloroamphetamine and H75/12 in rats. Brain Res. 1992 Oct 30;594(2):323-6. | ||||
| REF 4 | Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82. | ||||
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