Drug Information

Drug General Information
Drug ID
D00EWR
Former ID
DCL000311
Drug Name
Fidarestat
Synonyms
Aldos; FID; Fidaresstat; SK 860; Snk 860; Aldos (TN); SNK-860; Fidarestat (JAN/INN); (+)-(2S,4S)-6-Fluoro-2',5'-dioxospiro(chroman-4,4'-imidazolidine)-2-carboxamide; (+)-(2s,4s)-6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide; (2S,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE; (2S,4S)-6-Fluoro-2',5'-dioxospiro(3,4-dihydro-2H-1-benzopyran-4,4'-imidazolidine)-2-carboxamide; (2S,4S)-6-fluoro-2',5'-dioxospiro(chroman-4,4'-imidazolidine)-2-carboxamide; (2S,4S)-6-fluoro-2',5'-dioxospiro[2,3-dihydrochromene-4,4'-imidazolidine]-2-carboxamide
Drug Type
Small molecular drug
Indication Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1] Phase 3 [532182]
Company
Sanwa Kagaku
Structure
Download
2D MOL

3D MOL
Formula
C12H10FN3O4
Canonical SMILES
C1C(OC2=C(C13C(=O)NC(=O)N3)C=C(C=C2)F)C(=O)N
InChI
1S/C12H10FN3O4/c13-5-1-2-7-6(3-5)12(4-8(20-7)9(14)17)10(18)15-11(19)16-12/h1-3,8H,4H2,(H2,14,17)(H2,15,16,18,19)/t8-,12-/m0/s1
InChIKey
WAAPEIZFCHNLKK-UFBFGSQYSA-N
CAS Number
CAS 136087-85-9
PubChem Compound ID
160024
PubChem Substance ID
829889, 838229, 7848904, 7887485, 7979347, 8026646, 10253854, 12014775, 14775245, 14897486, 24698193, 24698198, 24698203, 46235162, 46516744, 49661428, 49661458, 49661462, 50046795, 57646652, 71821327, 77292494, 92729634, 103065812, 103065813, 103077006, 103077007, 103286645, 113443802, 117510930, 129551705, 134338967, 135115519, 137255424, 137267441, 144206034, 162007927, 162011895, 162189200, 162788466, 163418482, 163850157, 172856163, 174527334, 179149856, 189562728, 198958698, 223554789, 223658378, 226432692
Target and Pathway
Target(s) Aldose reductase Target Info Inhibitor [535270], [538074]
BioCyc Pathway Methylglyoxal degradation III
Acetone degradation I (to methylglyoxal)
KEGG Pathway Pentose and glucuronate interconversions
Fructose and mannose metabolism
Galactose metabolism
Glycerolipid metabolism
Metabolic pathways
NetPath Pathway IL1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway Fructose and Mannose Degradation
Pyruvate Metabolism
Pterine Biosynthesis
Glycerolipid Metabolism
Galactose Metabolism
WikiPathways Metapathway biotransformation
Polyol Pathway
Metabolism of steroid hormones and vitamin D
References
Ref 532182X-ray structure of the V301L aldo-keto reductase 1B10 complexed with NADP(+) and the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity. Chem Biol Interact. 2013 Feb 25;202(1-3):178-85.
Ref 535270Clinical efficacy of fidarestat, a novel aldose reductase inhibitor, for diabetic peripheral neuropathy: a 52-week multicenter placebo-controlled double-blind parallel group study. Diabetes Care. 2001 Oct;24(10):1776-82.
Ref 538074Aldose reductase inhibitor SNK-860. Nippon Rinsho. 1997 Nov;55 Suppl:212-5.

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