Drug General Information
Drug ID	D00EBH
Former ID	DIB009413
Drug Name	ICI-170809
Synonyms	ZM-170809
Drug Type	Small molecular drug
Indication	Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42]		Discontinued in Phase 2	[544978]
Company	Zeneca Group plc
Structure		Download 2D MOL 3D MOL
Formula	C21H24N2S
Canonical SMILES	c1(nc2c(cc1c1ccccc1)cccc2)SCC(N(C)C)(C)C.Cl
CAS Number	CAS 85275-49-6
PubChem Compound ID	134946
Target and Pathway
Target(s)	5-HT 2 receptor	Target Info	Modulator	[533671]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channels
References
Ref 544978	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001766)
Ref 533671	5-HT2 receptor blockade by ICI 170,809 does not affect the inhibitory effect of the 5-HT1A receptor ligand gepirone on neuroleptic-induced catalepsy. Braz J Med Biol Res. 1994 Oct;27(10):2437-41.

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