Drug Information

Drug General Information
Drug ID
D00DRL
Former ID
DIB018001
Drug Name
MK-2461
Synonyms
MK 2461
Drug Type
Small molecular drug
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Phase 1/2 [530708]
Structure
Download
2D MOL
Formula
C24H25N5O5S
InChI
InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
InChIKey
JGEBLDKNWBUGRZ-HXUWFJFHSA-N
PubChem Compound ID
44137946
PubChem Substance ID
99311589, 120085564, 134434312, 136354345, 137621135, 152159588, 162011940, 172650578, 174006529, 185992946, 198939386, 202535697, 224067724, 225848214, 226471300, 242587360, 244162949, 249565645, 252472482, 252543420
Target and Pathway
Target(s) Vascular endothelial growth factor receptor 3 Target Info Inhibitor [530708]
Mertk Target Info Inhibitor [530708]
FL cytokine receptor Target Info Inhibitor [530708]
Hepatocyte growth factor receptor Target Info Inhibitor [530708]
Basic fibroblast growth factor receptor 1 Target Info Inhibitor [530708]
Beta platelet-derived growth factor receptor Target Info Inhibitor [530708]
Vascular endothelial growth factor receptor 2 Target Info Inhibitor [530708]
mRNA of VEGFR1 Target Info Inhibitor [530708]
FGF-3 receptor Target Info Inhibitor [530708]
Trk receptor Target Info Inhibitor [530708]
BDNF/NT-3 growth factors receptor Target Info Inhibitor [530708]
Fibroblast growth factor receptor 2 Target Info Inhibitor [530708]
RON Target Info Inhibitor [530708]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Focal adhesionhsa04060:Cytokine-cytokine receptor interaction
Hematopoietic cell lineage
Pathways in cancer
Transcriptional misregulation in cancer
Acute myeloid leukemia
Central carbon metabolism in cancerhsa04014:Ras signaling pathway
Endocytosis
Axon guidance
Focal adhesion
Adherens junction
Bacterial invasion of epithelial cells
Epithelial cell signaling in Helicobacter pylori infection
Malaria
Proteoglycans in cancer
MicroRNAs in cancer
Renal cell carcinoma
Melanoma
Central carbon metabolism in cancerhsa04010:MAPK signaling pathway
Signaling pathways regulating pluripotency of stem cells
Regulation of actin cytoskeleton
Prostate cancer
Calcium signaling pathway
Gap junction
HTLV-I infection
Glioma
Central carbon metabolism in cancer
Choline metabolism in cancerhsa04014:Ras signaling pathway
VEGF signaling pathway
Proteoglycans in cancerhsa04014:Ras signaling pathway
HIF-1 signaling pathway
Rheumatoid arthritishsa04010:MAPK signaling pathway
Bladder cancer
Neurotrophin signaling pathway
Alcoholismhsa04010:MAPK signaling pathway
NetPath Pathway TNFalpha Signaling PathwayNetPath_23:TSH Signaling PathwayNetPath_11:TCR Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_13:IL1 Signaling Pathway
PANTHER Pathway Angiogenesis
FGF signaling pathwayP00005:Angiogenesis
PDGF signaling pathwayP00005:Angiogenesis
VEGF signaling pathwayP00021:FGF signaling pathwayP00021:FGF signaling pathway
Pathway Interaction Database VEGF and VEGFR signaling network
VEGFR3 signaling in lymphatic endotheliummet_pathway:Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Arf6 signaling events
Signaling events mediated by TCPTP
Posttranslational regulation of adherens junction stability and dissassembly
Direct p53 effectors
Syndecan-1-mediated signaling events
Stabilization and expansion of the E-cadherin adherens junction
a6b1 and a6b4 Integrin signaling
FGF signaling pathway
Regulation of retinoblastoma proteinglypican_1pathway:Glypican 1 network
Syndecan-4-mediated signaling events
N-cadherin signaling events
FGF signaling pathwayptp1bpathway:Signaling events mediated by PTP1B
Beta3 integrin cell surface interactions
S1P3 pathway
Nectin adhesion pathway
SHP2 signaling
S1P1 pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
PDGFR-beta signaling pathway
Validated targets of C-MYC transcriptional repression
PDGF receptor signaling networkhif2pathway:HIF-2-alpha transcription factor network
Integrins in angiogenesis
Signaling events mediated by VEGFR1 and VEGFR2
Notch-mediated HES/HEY networkglypican_1pathway:Glypican 1 network
HIF-2-alpha transcription factor network
VEGFR1 specific signals
Signaling events mediated by VEGFR1 and VEGFR2shp2_pathway:SHP2 signaling
Neurotrophic factor-mediated Trk receptor signalingfgf_pathway:FGF signaling pathwayamb2_neutrophils_pathway:amb2 Integrin signaling
Reactome VEGF binds to VEGFR leading to receptor dimerizationR-HSA-202733:Cell surface interactions at the vascular wallR-HSA-416550:Sema4D mediated inhibition of cell attachment and migrationR-HSA-1257604:PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascadeR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerization
Integrin cell surface interactions
EPHA-mediated growth cone collapse
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferationR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerizationR-HSA-2033514:FGFR3 mutant receptor activationR-HSA-170984:ARMS-mediated activation
NGF-independant TRKA activation
PI3K/AKT activationR-HSA-187024:NGF-independant TRKA activationR-HSA-2033519:Activated point mutants of FGFR2
WikiPathways Signaling by VEGFWP1794:Cell surface interactions at the vascular wallWP366:TGF beta Signaling Pathway
Signaling of Hepatocyte Growth Factor Receptor
Focal Adhesion
Extracellular vesicle-mediated signaling in recipient cells
Signaling Pathways in Glioblastoma
miR-targeted genes in squamous cell - TarBase
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
Semaphorin interactionsWP51:Regulation of Actin Cytoskeleton
Endochondral Ossification
MAPK Signaling Pathway
Mesodermal Commitment Pathway
Hair Follicle Development: Induction (Part 1 of 3)
Integrated Pancreatic Cancer Pathway
Neural Crest Differentiation
Signaling by FGFRWP51:Regulation of Actin Cytoskeleton
Osteoblast Signaling
PIP3 activates AKT signaling
PDGF Pathway
Signaling by PDGFWP306:Focal Adhesion
Nifedipine Activity
Cardiac Progenitor Differentiation
Signaling by VEGF
AngiogenesisWP306:Focal Adhesion
AngiogenesisWP51:Regulation of Actin Cytoskeleton
Bladder Cancer
Signaling by FGFRWP382:MAPK Signaling Pathway
BDNF signaling pathway
NGF signalling via TRKA from the plasma membraneWP706:SIDS Susceptibility Pathways
BDNF signaling pathwayWP51:Regulation of Actin Cytoskeleton
Ectoderm Differentiation
Hair Follicle Development: Organogenesis (Part 2 of 3)
Cardiac Hypertrophic Response
Signaling by FGFR
MicroRNAs in cardiomyocyte hypertrophy
Angiogenesis
References
Ref 530708MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Cancer Res. 2010 Feb 15;70(4):1524-33.
Ref 530708MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Cancer Res. 2010 Feb 15;70(4):1524-33.

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