Drug General Information |
Drug ID |
D00AUX
|
Former ID |
DNCL002894
|
Drug Name |
MSDC-0602
|
Drug Type |
Small molecular drug
|
Indication |
Type 2 diabetes [ICD9: 250; ICD10:E11]
|
Phase 2 |
[1]
|
Company |
Metabolic Solutions Development
|
Structure |
|
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2D MOL
3D MOL
|
Formula |
C19H17NO5S
|
PubChem Compound ID |
|
Target and Pathway |
Target(s) |
Insulin receptor |
Target Info |
Modulator |
[2]
|
KEGG Pathway
|
Ras signaling pathway
|
Rap1 signaling pathway
|
cGMP-PKG signaling pathway
|
HIF-1 signaling pathway
|
FoxO signaling pathway
|
PI3K-Akt signaling pathway
|
AMPK signaling pathway
|
Adherens junction
|
Insulin signaling pathway
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Ovarian steroidogenesis
|
Type II diabetes mellitus
|
Non-alcoholic fatty liver disease (NAFLD)
|
Aldosterone-regulated sodium reabsorption
|
NetPath Pathway
|
TGF_beta_Receptor Signaling Pathway
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PANTHER Pathway
|
Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
|
Insulin/IGF pathway-protein kinase B signaling cascade
|
PI3 kinase pathway
|
Pathway Interaction Database
|
Insulin Pathway
|
Signaling events mediated by PTP1B
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Signaling events mediated by TCPTP
|
Insulin-mediated glucose transport
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PathWhiz Pathway
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Insulin Signalling
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Leucine Stimulation on Insulin Signaling
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Reactome
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IRS activation
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Signal attenuation
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Insulin receptor signalling cascade
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Insulin receptor recycling
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WikiPathways
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DNA Damage Response (only ATM dependent)
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Insulin Signaling
|
Nanoparticle triggered autophagic cell death
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AGE/RAGE pathway
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Signaling by Insulin receptor
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Folate Metabolism
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Type II diabetes mellitus
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Vitamin B12 Metabolism
|
Selenium Micronutrient Network
|
AMPK Signaling
|
References |
REF 1 | ClinicalTrials.gov (NCT01280695) A Randomized, Double-Blind, Comparator- and Placebo-Controlled, Multiple-Dose Study to Evaluate the Safety, Tolerability and Efficacy of Three Dose Levels of MSDC-0602 in Type 2 Diabetic Patients. U.S. National Institutes of Health. |
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REF 2 | Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor gamma-sparing thiazolidinedione. J Biol Chem. 2012 Jul 6;287(28):23537-48. |