Target General Infomation
Target ID
T93662
Former ID
TTDI02275
Target Name
Hyaluronidase
Target Type
Successful
Disease Immunodeficiency [ICD9: 279.3; ICD10: D84.9]
Pancreatic cancer [ICD9: 140-199, 140-229, 157, 210-229; ICD10: C25]
Schizophrenia; Bipolar disorder [ICD9: 295, 296; ICD10: F20, F31]
BioChemical Class
Glycosylases
EC Number
EC 3.2.1.35
Drugs and Mode of Action
Drug(s) Asenapine Drug Info Approved Schizophrenia; Bipolar disorder [530677], [539399]
Hyqvia Drug Info Approved Immunodeficiency [533123]
PEGPH20 Drug Info Phase 2 Pancreatic cancer [524270]
PEGylated hyaluronidase (human recombinant) Drug Info Phase 1/2 Pancreatic cancer [525072]
Modulator Asenapine Drug Info [556264]
Hyqvia Drug Info [533123]
PEGPH20 Drug Info [1572591]
PEGylated hyaluronidase (human recombinant) Drug Info [544201]
References
Ref 524270ClinicalTrials.gov (NCT01839487) PEGPH20 Plus Nab-Paclitaxel Plus Gemcitabine Compared With Nab-Paclitaxel Plus Gemcitabine in Subjects With Stage IV Untreated Pancreatic Cancer. U.S. National Institutes of Health.
Ref 525072ClinicalTrials.gov (NCT02346370) A Phase 1b/2, Study of Pegylated Recombinant Human Hyaluronidase Combined With Docetaxel Versus Docetaxel Alone in Subjects With Recurrent Previously Treated Locally Advanced or Metastatic NSCLC.. U.S. National Institutes of Health.
Ref 530677Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
Ref 5331232014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
Ref 539399(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 22).
Ref
Ref 5331232014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
Ref 544201Targeting the tumor microenvironment in cancer: why hyaluronidase deserves a second look. Cancer Discov. 2011 September; 1(4): 291-296.
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
Ref 1572591Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.

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