Target Information
Target General Infomation | |||||
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Target ID |
T93509
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Former ID |
TTDC00017
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Target Name |
Calcitonin gene-related peptide 1
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Gene Name |
CALCA
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Synonyms |
Alpha-type CGRP; CALC1; CGRP-I; Calcitonin gene-related peptide I; CALCA
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Target Type |
Clinical Trial
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Disease | Neuropathic pain [ICD9: 356.0, 356.8; ICD10: G64, G90.0] | ||||
Function |
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP.
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BioChemical Class |
Cytotoxic amylin family
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Target Validation |
T93509
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UniProt ID | |||||
Sequence |
MGFQKFSPFLALSILVLLQAGSLHAAPFRSALESSPADPATLSEDEARLLLAALVQNYVQ
MKASELEQEQEREGSRIIAQKRACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAFG RRRRDLQA |
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Drugs and Mode of Action | |||||
Inhibitor | Ac-VTHRLAGLLSRSGGVVKNNFVPTDVGPFAF-NH2 | Drug Info | [529839] | ||
Ac-VTHRLAGLLSRSGGVVRKNFVPTDVGPFAF-NH2 | Drug Info | [529839] | |||
Ac-WVEHRLKGELSRKGGVV[hArg]KNFVPTDVGPFAF-NH2 | Drug Info | [529839] | |||
Ac-WVTHQLAGLLSQSGGVVRKNFVPTDVGPFAF-NH2 | Drug Info | [529839] | |||
Ac-WVTHRLAGLLSRSGGVVRKNFVPTDVGPFAF-NH2 | Drug Info | [529839] | |||
Ac-WVTHRLAGLLS[Cit]SGGVVRKNFVPTDVGPFAF-NH2 | Drug Info | [529839] | |||
Ac-WVTH[Cit]LAGLLSRSGGVVRKNFVPTDVGPFAF-NH2 | Drug Info | [529839] | |||
Ac-WVTH[Cit]LAGLLS[Cit]SGGVVRKNFVPTDVGPFAF-NH2 | Drug Info | [529839] | |||
Ac-WVTH[hArg]LAGLLS[hArg]SGGVVRKNFVPTDVGPFAF-NH2 | Drug Info | [529839] | |||
Cizolirtine | Drug Info | [536374] | |||
FV-Aib-TDVGPFAF | Drug Info | [529839] | |||
VTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH2 | Drug Info | [529839] | |||
WVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH2 | Drug Info | [529839] | |||
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
References |
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