Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T88430
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| Former ID |
TTDR01370
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| Target Name |
mRNA of A-Raf
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| Gene Name |
ARAF
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| Synonyms |
Proto-oncogene A-Raf (mRNA); Proto-oncogene A-Raf-1 (mRNA); Proto-oncogene Pks (mRNA); Serine/threonine-protein kinase A-Raf (mRNA); ARAF
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| Target Type |
Clinical Trial
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| Disease | Solid tumours [ICD9: 140-199, 210-229; ICD10: C00-D48] | ||||
| Function |
Isoform 2: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation.
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| BioChemical Class |
Kinase
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| UniProt ID | |||||
| EC Number |
EC 2.7.11.1
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| Sequence |
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELL TPQGPSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFS TDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSG YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRK TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS AARLVP |
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| Drugs and Mode of Action | |||||
| Pathways | |||||
| KEGG Pathway | ErbB signaling pathway | ||||
| FoxO signaling pathway | |||||
| Vascular smooth muscle contraction | |||||
| Natural killer cell mediated cytotoxicity | |||||
| Long-term potentiation | |||||
| Serotonergic synapse | |||||
| Long-term depression | |||||
| Regulation of actin cytoskeleton | |||||
| Insulin signaling pathway | |||||
| Progesterone-mediated oocyte maturation | |||||
| Alcoholism | |||||
| Hepatitis C | |||||
| Pathways in cancer | |||||
| Proteoglycans in cancer | |||||
| Colorectal cancer | |||||
| Renal cell carcinoma | |||||
| Pancreatic cancer | |||||
| Endometrial cancer | |||||
| Glioma | |||||
| Prostate cancer | |||||
| Melanoma | |||||
| Bladder cancer | |||||
| Chronic myeloid leukemia | |||||
| Acute myeloid leukemia | |||||
| Non-small cell lung cancer | |||||
| PANTHER Pathway | Angiogenesis | ||||
| B cell activation | |||||
| Integrin signalling pathway | |||||
| Interleukin signaling pathway | |||||
| PDGF signaling pathway | |||||
| T cell activation | |||||
| VEGF signaling pathway | |||||
| Ras Pathway | |||||
| CCKR signaling map ST | |||||
| Reactome | RAF activation | ||||
| MAP2K and MAPK activation | |||||
| Negative regulation of MAPK pathway | |||||
| WikiPathways | ErbB Signaling Pathway | ||||
| MAPK Cascade | |||||
| Signaling Pathways in Glioblastoma | |||||
| Integrated Breast Cancer Pathway | |||||
| Integrin-mediated Cell Adhesion | |||||
| References | |||||
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