Target Information

Target General Infomation
Target ID
T86541
Former ID
TTDI02591
Target Name
Amiloride sensitive cation channel 1
Gene Name
ASIC2
Synonyms
Acidsensing ion channel 2; Amiloridesensitive brain sodium channel; Amiloridesensitive cation channel1, neuronal; Amiloridesensitive cation channelneuronal 1; BNC1; BNaC1; Brain sodium channel 1; Mammalian degenerin homolog; ASIC2
Target Type
Research
Disease Neuropathic pain [ICD9: 356.0, 356.8; ICD10: G64, G90.0]
Function
Cation channel with high affinityfor sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.
BioChemical Class
Amiloride-sensitive sodium channel
UniProt ID
Q16515
Sequence
MDLKESPSEGSLQPSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVES
SERVSYYFSYQHVTKVDEVVAQSLVFPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDVN
LQIPDPHLADPSVLEALRQKANFKHYKPKQFSMLEFLHRVGHDLKDMMLYCKFKGQECGH
QDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTF
EAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFP
VYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLC
RTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQK
KAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEEDEGSHDENVS
TCDTMPNHSETISHTVNVPLQTTLGTLEEIAC
Blocker (channel blocker) A-317567 Drug Info [543914]
Antagonist THA-904 Drug Info [543914]
Pathways
KEGG Pathway Taste transduction
Inflammatory mediator regulation of TRP channels
Reactome Stimuli-sensing channels
WikiPathways Iron uptake and transport
References
Ref 543914(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 685).

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.