Target Information

Target General Infomation
Target ID
T86194
Target Name
GABA B receptor
Target Type
Clinical Trial
Disease Autism; Fragile X syndrome [ICD9:299, 332, 759.83; ICD10: F84.0, F02.3, G20, Q99.2]
Epilepsy [ICD10: G40]
Fragile X syndrome [ICD9: 332, 759.83; ICD10: F02.3, G20, Q99.2]
Gastroesophageal reflux disease [ICD9: 140-229, 530; ICD10: K21]
Hypertonia [ICD10: P94.1]
Unspecified [ICD code not available]
BioChemical Class
G protein-coupled receptors (GPCR)
Drugs and Mode of Action
Drug(s) Arbaclofen placarbil Drug Info Phase 3 Fragile X syndrome [523413]
SSTarbaclofen Drug Info Phase 2 Autism; Fragile X syndrome [523344], [550082]
ADX-71943 Drug Info Preclinical Gastroesophageal reflux disease [548279]
SUN-09 Drug Info Discontinued in Phase 3 Hypertonia [549477]
AZD3355 Drug Info Discontinued in Phase 2 Gastroesophageal reflux disease [542680], [547426]
AZD-9343 Drug Info Discontinued in Phase 1 Gastroesophageal reflux disease [547681]
CGP-35348 Drug Info Terminated Epilepsy [538651], [545201]
Modulator ADX-71943 Drug Info [532842]
Arbaclofen placarbil Drug Info
AVE-1876 Drug Info
AZD-9343 Drug Info [530291]
AZD3355 Drug Info
CGP 36742 Drug Info
CGP-35348 Drug Info
SSTarbaclofen Drug Info
SUN-09 Drug Info
References
Ref 523344ClinicalTrials.gov (NCT01288716) Study of Arbaclofen for the Treatment of Social Withdrawal in Subjects With Autism Spectrum Disorders. U.S. National Institutes of Health.
Ref 523413ClinicalTrials.gov (NCT01325220) Efficacy and Safety Study of STX209 (Arbaclofen) for the Treatment of Social Withdrawal in Children With Fragile X Syndrome. U.S. National Institutes of Health.
Ref 538651(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1069).
Ref 542680(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7705).
Ref 545201Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002440)
Ref 547426Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016139)
Ref 547681Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018389)
Ref 548279Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024111)
Ref 549477Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800038116)
Ref 550082Effects of STX209 (Arbaclofen) on Neurobehavioral Function in Children and Adults with Fragile X Syndrome: A Randomized, Controlled, Phase 2 Trial. Science Translational Medicine Vol 4, Issue 152 19 September 2012.
Ref 530291The GABA(B) receptor agonist AZD9343 inhibits transient lower oesophageal sphincter relaxations and acid reflux in healthy volunteers: a phase I study. Aliment Pharmacol Ther. 2009 Nov 1;30(9):937-46.
Ref 532842Evaluation of peripheral versus central effects of GABA(B) receptor activation using a novel, positive allosteric modulator of the GABA(B) receptor ADX71943, a pharmacological tool compound with a fully peripheral activity profile. Br J Pharmacol. 2014 Nov;171(21):4941-54.

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