Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T85309
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| Former ID |
TTDR00526
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| Target Name |
Cystathionine beta-synthase
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| Gene Name |
CBS
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| Synonyms |
Beta-thionase; Serine sulfhydrase; CBS
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| Target Type |
Research
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| Function |
Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury (By similarity).
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| BioChemical Class |
Carbon-oxygen lyases
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| UniProt ID | |||||
| EC Number |
EC 4.2.1.22
|
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| Sequence |
MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWIRPDAPSRCTWQLGRPA
SESPHHHTAPAKSPKILPDILKKIGDTPMVRINKIGKKFGLKCELLAKCEFFNAGGSVKD RISLRMIEDAERDGTLKPGDTIIEPTSGNTGIGLALAAAVRGYRCIIVMPEKMSSEKVDV LRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSHILDQYRNASNPLAHYDTTADEI LQQCDGKLDMLVASVGTGGTITGIARKLKEKCPGCRIIGVDPEGSILAEPEELNQTEQTT YEVEGIGYDFIPTVLDRTVVDKWFKSNDEEAFTFARMLIAQEGLLCGGSAGSTVAVAVKA AQELQEGQRCVVILPDSVRNYMTKFLSDRWMLQKGFLKEEDLTEKKPWWWHLRVQELGLS APLTVLPTITCGHTIEILREKGFDQAPVVDEAGVILGMVTLGNMLSSLLAGKVQPSDQVG KVIYKQFKQIRLTDTLGRLSHILEMDHFALVVHEQIQYHSTGKSSQRQMVFGVVTAIDLL NFVAAQERDQK |
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| Inhibitor | aminooxyacetic acid | Drug Info | [1] | ||
| Heme | Drug Info | [2] | |||
| Pathways | |||||
| BioCyc Pathway | Hydrogen sulfide biosynthesis (trans-sulfuration) | ||||
| Cysteine biosynthesis/homocysteine degradation (trans-sulfuration) | |||||
| Superpathway of methionine degradation | |||||
| Cysteine biosynthesis | |||||
| KEGG Pathway | Glycine, serine and threonine metabolism | ||||
| Cysteine and methionine metabolism | |||||
| Metabolic pathways | |||||
| Biosynthesis of antibiotics | |||||
| Biosynthesis of amino acids | |||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
| PANTHER Pathway | Cysteine biosynthesis | ||||
| PathWhiz Pathway | Selenoamino Acid Metabolism | ||||
| Homocysteine Degradation | |||||
| Methionine Metabolism | |||||
| Glycine and Serine Metabolism | |||||
| WikiPathways | Vitamin D Receptor Pathway | ||||
| Metabolism of amino acids and derivatives | |||||
| Trans-sulfuration and one carbon metabolism | |||||
| Trans-sulfuration pathway | |||||
| Folate Metabolism | |||||
| Folate-Alcohol and Cancer Pathway | |||||
| Vitamin B12 Metabolism | |||||
| Selenium Micronutrient Network | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1443). | ||||
| REF 2 | The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. | ||||
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