Target Information

Target General Infomation
Target ID
T82075
Former ID
TTDR00969
Target Name
Celldivision protein FtsZ
Gene Name
ftsZ
Synonyms
FtsZ; FtsZprotein; ftsZ
Target Type
Research
Function
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
BioChemical Class
Peptidase
UniProt ID
P45485
EC Number
EC 3.4.24.-
Sequence
MSIDLSLPELPILHPRITVVGVGGAGGNAVNNMIQSNLQGVNFVVANTDAQALEKSLCDK
KIQLGINLTKGLGAGALPDVGKGAAEESIDEIMEHIKDSHMLFITAGMGGGTGTGAAPVI
AKAAREARAAVKDRAPKEKKILTVGVVTKPFGFEGVRRMPIAELGLEELQKYVDTLIVIP
NQNLFRIANEKTTFSDAFKLADNVLHIGIRGVTDLMVMPGLINLDFADIETVMSEMGKAM
IGTGEAEGEDRAISAAEAAISNPLLDNVSMKGAQGILINITGGGDMTLFEVDAAANRVRE
EVDENANIIFGATFDQAMEGRVRVSVLATGIDGRNNKSETSPISQSEDSEKEKFKWPYSQ
SESTQDKTLETKPAEQVSEGAKWGSNIYDIPAYLRRKK
Inhibitor 5'-Guanosine-Diphosphate-Monothiophosphate Drug Info [551393]
Guanosine-5'-Diphosphate Drug Info [551393]
Phosphomethylphosphonic Acid Guanylate Ester Drug Info [551393]
References
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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