Target Information
Target General Infomation | |||||
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Target ID |
T77139
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Former ID |
TTDR01005
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Target Name |
Mitogen-activated protein kinasekinase kinase 3
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Gene Name |
MAP3K3
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Synonyms |
MAPK/ERK kinase kinase 3; MEK kinase 3; MEKK 3; MEKK3; MAP3K3
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Target Type |
Research
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Function |
Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators.
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BioChemical Class |
Kinase
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UniProt ID | |||||
EC Number |
EC 2.7.11.25
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Sequence |
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAF
SRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILL LSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPPEPRSRHLSVSSQNPGRSSPPPG YVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPSF RKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGGTYPRRYHVSVHHKDYSDGRRTFPRIRR HQGNLFTLVPSSRSLSTNGENMGLAVQYLDPRGRLRSADSENALSVQERNVPTKSPSAPI NWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQ HERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYL HSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVIS GEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFL RRIFVEARQRPSAEELLTHHFAQLMY |
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Pathways | |||||
NetPath Pathway | TSH Signaling Pathway | ||||
PANTHER Pathway | B cell activation | ||||
EGF receptor signaling pathway | |||||
FGF signaling pathway | |||||
Pathway Interaction Database | p38 MAPK signaling pathway | ||||
Regulation of p38-alpha and p38-beta | |||||
IL1-mediated signaling events | |||||
TNF receptor signaling pathway | |||||
Reactome | Interleukin-1 signaling | ||||
WikiPathways | Insulin Signaling | ||||
EGF/EGFR Signaling Pathway | |||||
MAPK Cascade | |||||
Structural Pathway of Interleukin 1 (IL-1) | |||||
EBV LMP1 signaling | |||||
TNF alpha Signaling Pathway | |||||
IL-1 signaling pathway | |||||
Interleukin-1 signaling | |||||
References |
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