Target Information
Target General Infomation | |||||
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Target ID |
T76024
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Former ID |
TTDC00085
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Target Name |
C1 esterase
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Gene Name |
C1S
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Synonyms |
C1 esterase; C1-esterase; C1S
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Target Type |
Successful
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Disease | Hereditary angioedema [ICD9: 277.6; ICD10: D84.1] | ||||
Stroke [ICD9: 434.91, 437.6, 453, 671.5, 671.9; ICD10: I61-I63, I80-I82] | |||||
Function |
C1s b chain is a serine protease that combineswith c1q and c1s to form c1, the first component of the classical pathway of the complement system. C1r activates c1s so that it can, in turn, activate c2 and c4.
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BioChemical Class |
Peptidase
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Target Validation |
T76024
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UniProt ID | |||||
EC Number |
EC 3.4.21.42
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Sequence |
MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIE
LSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERF TGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVF TALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVF VAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTP NSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCG IPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPK CVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGN REPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVK MGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKV EKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCG TYGLYTRVKNYVDWIMKTMQENSTPRED |
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Drugs and Mode of Action | |||||
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
KEGG Pathway | Complement and coagulation cascades | ||||
Pertussis | |||||
Staphylococcus aureus infection | |||||
Systemic lupus erythematosus | |||||
NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
WikiPathways | Complement and Coagulation Cascades | ||||
Complement Activation, Classical Pathway | |||||
Human Complement System | |||||
Complement cascade | |||||
References |
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