Target Information

Target General Infomation
Target ID
T70792
Former ID
TTDNS00541
Target Name
Placental growth factor
Gene Name
PGF
Synonyms
PlGF; PGFL; PLGF; D12S1900; PlGF-2; SHGC-10760; PGF
Target Type
Successful
Disease Metastatic colorectal cancer [ICD9: 153, 154; ICD10: C18-C21]
Function
Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.
BioChemical Class
PIGF family
UniProt ID
P49763
Sequence
MPVMRLFPCFLQLLAGLALPAVPPQQWALSAGNGSSEVEVVPFQEVWGRSYCRALERLVD
VVSEYPSEVEHMFSPSCVSLLRCTGCCGDENLHCVPVETANVTMQLLKIRSGDRPSYVEL
TFSQHVRCECRHSPGRQSPDMPGDFRADAPSFLPPRRSLPMLFRMEWGCALTGSQSAVWP
SSPVPEEIPRMHPGRNGKKQQRKPLREKMKPERCGDAVPRR
Drugs and Mode of Action
Drug(s) Aflibercept Drug Info Approved Metastatic colorectal cancer [551871]
Modulator Aflibercept Drug Info [551871]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
Metabolic pathways
NetPath Pathway TCR Signaling Pathway
WikiPathways Diurnally Regulated Genes with Circadian Orthologs
synthesis of GPI-anchored proteins
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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