Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T70065
|
||||
| Former ID |
TTDR00167
|
||||
| Target Name |
Dihydroorotase
|
||||
| Gene Name |
dho
|
||||
| Synonyms |
DHOase; dho
|
||||
| Target Type |
Research
|
||||
| BioChemical Class |
Carbon-nitrogen hydrolase
|
||||
| UniProt ID | |||||
| EC Number |
EC 3.5.2.3
|
||||
| Sequence |
MKNYFYIPIADDMHCHLRQGDMLDFTVNSIRRGGCNRVLVMPNTHPIISTCSDAQKYLYQ
LKSRDDDIEYLMTLYLNKNTDENDILSNYYKCNLQGVKIYPSNVTTNSSDGITSLEPYYK VFHALEKLNKSIHIHCEEPNINPLYAEEKYLPHIHDLAIKFPGLNIVLEHISSSESINVI KEFRNVAGSITPHHLYLTIDDVVNMDIYDHAIDNTYIEKYIKNTYHYCKPLPKLLEDKIA LQDVIKDDFPRVFLGSDSAPHYKVMKRKPYYKPGIYTQPFLINYVAHILNKFDALDKMEN FTSKNASLFLNLAEKKKLAKYYICVEKHPFKLPREYNGVVPFLAGKTLDYDIHYVSKF |
||||
| Inhibitor | 5-amino orotate | Drug Info | [1] | ||
| 5-bromo orotate | Drug Info | [1] | |||
| 5-Fluoro orotate | Drug Info | [1] | |||
| 5-iodo orotate | Drug Info | [1] | |||
| 5-methyl orotate | Drug Info | [1] | |||
| Dihydroorotic Acid | Drug Info | [2] | |||
| Lysine Nz-Carboxylic Acid | Drug Info | [2] | |||
| N-Carbamoyl-L-Aspartate | Drug Info | [2] | |||
| Orotate | Drug Info | [1] | |||
| References | |||||
| REF 1 | Antimalarial activity of orotate analogs that inhibit dihydroorotase and dihydroorotate dehydrogenase. Biochem Pharmacol. 1992 Mar 17;43(6):1295-301. | ||||
| REF 2 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.