Target Information

Target General Infomation
Target ID
T68834
Former ID
TTDI03427
Target Name
OXE receptor
Gene Name
OXER1
Synonyms
OXER1
Target Type
Research
UniProt ID
Q8TDS5
Sequence
MLCHRGGQLIVPIIPLCPEHSCRGRRLQNLLSGPWPKQPMELHNLSSPSPSLSSSVLPPS
FSPSPSSAPSAFTTVGGSSGGPCHPTSSSLVSAFLAPILALEFVLGLVGNSLALFIFCIH
TRPWTSNTVFLVSLVAADFLLISNLPLRVDYYLLHETWRFGAAACKVNLFMLSTNRTASV
VFLTAIALNRYLKVVQPHHVLSRASVGAAARVAGGLWVGILLLNGHLLLSTFSGPSCLSY
RVGTKPSASLRWHQALYLLEFFLPLALILFAIVSIGLTIRNRGLGGQAGPQRAMRVLAMV
VAVYTICFLPSIIFGMASMVAFWLSACRSLDLCTQLFHGSLAFTYLNSVLDPVLYCFSSP
NFLHQSRALLGLTRGRQGPVSDESSYQPSRQWRYREASRKAEAIGKLKVQGEVSLEKEGS
SQG
Antagonist 5-(6-chloro-2-hexyl-1H-indol-1-yl)-5-oxo-valeric acid Drug Info [532305]
5-oxo-12-HETE Drug Info [534822]
Agonist 5-oxo-15-HETE Drug Info [534106]
5-oxo-20-HETE Drug Info [534106]
5-oxo-C20:3 Drug Info [529330]
5-oxo-ETE Drug Info [526748]
5-oxo-ODE Drug Info [529321]
5S-HETE Drug Info [527658]
5S-HPETE Drug Info [527658]
[3H]5-oxo-ETE Drug Info [534758]
Modulator (allosteric modulator) Gue1654 Drug Info [531925]
References
Ref 526748Metabolism of 5(S)-hydroxy-6,8,11,14-eicosatetraenoic acid and other 5(S)-hydroxyeicosanoids by a specific dehydrogenase in human polymorphonuclear leukocytes. J Biol Chem. 1992 Sep 25;267(27):19233-41.
Ref 527658TG1019/OXE, a Galpha(i/o)-protein-coupled receptor, mediates 5-oxo-eicosatetraenoic acid-induced chemotaxis. Biochem Biophys Res Commun. 2005 Sep 9;334(4):987-95.
Ref 529321Human neutrophils convert the sebum-derived polyunsaturated fatty acid Sebaleic acid to a potent granulocyte chemoattractant. J Biol Chem. 2008 Apr 25;283(17):11234-43.
Ref 529330Structural requirements for activation of the 5-oxo-6E,8Z, 11Z,14Z-eicosatetraenoic acid (5-oxo-ETE) receptor: identification of a mead acid metabolite with potent agonist activity. J Pharmacol Exp Ther. 2008 May;325(2):698-707.
Ref 531925A biased ligand for OXE-R uncouples Galpha and Gbetagamma signaling within a heterotrimer. Nat Chem Biol. 2012 Jul;8(7):631-8.
Ref 5323055-Oxo-ETE receptor antagonists. J Med Chem. 2013 May 9;56(9):3725-32.
Ref 534106Metabolism and biologic effects of 5-oxoeicosanoids on human neutrophils. J Immunol. 1996 Jan 1;156(1):336-42.
Ref 534758Receptors for the 5-oxo class of eicosanoids in neutrophils. J Biol Chem. 1998 Dec 4;273(49):32535-41.
Ref 534822Biological inactivation of 5-oxo-6,8,11,14-eicosatetraenoic acid by human platelets. Blood. 1999 Feb 1;93(3):1086-96.

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